Genome-wide studies in prostate cancer poised liquid biopsy as a molecular discovery tool

被引：2

作者：

Lo, Nicholas ^{[1
]}

He, Housheng Hansen ^{[1
,2
]}

Chen, Sujun ^{[1
,3
,4
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[3] Sichuan Univ, West China Hosp 4, West China Sch Publ Hlth, Chengdu, Peoples R China

[4] Sichuan Univ, State Key Lab Biotherapy, Chengdu, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

关键词：

prostate cancer; liquid biopsy; deep genomic sequencing; genome-wide methylation analysis; disease progression; CIRCULATING TUMOR-CELLS; ABIRATERONE ACETATE; DNA; BIOMARKER; GENE; SURVIVAL; 5-HYDROXYMETHYLCYTOSINE; MICRORNAS; TRIALS; ASSAY;

D O I：

10.3389/fonc.2023.1185013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liquid biopsy is emerging as an intriguing tool in clinical disease detection and monitoring. Compared to a standard tissue biopsy, performing a liquid biopsy incurs minimal invasiveness, captures comprehensive disease representation, and can be more sensitive at an early stage. Recent genome-wide liquid biopsy studies in prostate cancer analyzing plasma samples have provided insights into the genome and epigenome dynamics during disease progression. In-depth genomic sequencing can offer a comprehensive understanding of cancer evolution, enabling more accurate clinical decision-making. Furthermore, exploring beyond the DNA sequence itself provides opportunities to investigate the regulatory mechanisms underlying various disease phenotypes. Here, we summarize these advances and offer prospects for their future application.

引用

页数：6

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