LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations

被引：55

作者：

Li, Zhao ^{[1
,2
,3
,4
]}

Liu, Lin ^{[1
,2
,3
]}

Feng, Changrui ^{[1
,2
,3
,4
]}

Qin, Yuxin ^{[1
,2
,3
,4
]}

Xiao, Jingfa ^{[1
,2
,3
,4
]}

Zhang, Zhang ^{[1
,2
,3
,4
]}

Ma, Lina ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Sci, Natl Genom Data Ctr, Beijing Inst Genom, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing 100101, Peoples R China

[3] China Natl Ctr Bioinformat, Beijing 100101, Peoples R China

[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2023年 / 51卷 / D1期

基金：

中国国家自然科学基金;

关键词：

PREDICTION; DATABASE; ATLAS;

D O I：

10.1093/nar/gkac999

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LncBook, a comprehensive resource of human long non-coding RNAs (lncRNAs), has been used in a wide range of lncRNA studies across various biological contexts. Here, we present LncBook 2.0 (https://ngdc.cncb.ac.cn/lncbook), with significant updates and enhancements as follows: (i) incorporation of 119 722 new transcripts, 9632 new genes, and gene structure update of 21 305 lncRNAs; (ii) characterization of conservation features of human lncRNA genes across 40 vertebrates; (iii) integration of lncRNA-encoded small proteins; (iv) enrichment of expression and DNA methylation profiles with more biological contexts and (v) identification of lncRNA-protein interactions and improved prediction of lncRNA-miRNA interactions. Collectively, LncBook 2.0 accommodates a high-quality collection of 95 243 lncRNA genes and 323 950 transcripts and incorporates their abundant annotations at different omics levels, thereby enabling users to decipher functional significance of lncRNAs in different biological contexts.

引用

页码：D186 / D191

页数：6

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