Potential biomarkers for alleviation of Streptococcus pneumoniae pneumonia by QingFei Yin

被引：0

作者：

Sun, Hai-Hang ^{[1
]}

Ding, Li-Zhong ^{[2
]}

Yu, Peng ^{[1
]}

Guo, Yun-Long ^{[1
]}

Huang, Xin ^{[1
]}

Fan, Mei-Ling ^{[3
]}

Sun, Li-Ping ^{[2
]}

Dai, Yu-Lin ^{[1
]}

机构：

[1] Changchun Univ Chinese Med, Changchun 130117, Peoples R China

[2] Changchun Univ Chinese Med, Dept Pediat, Affiliated Hosp 1, Changchun 130021, Peoples R China

[3] Changchun Univ Chinese Med, Obstet & Gynecol Clin, Affiliated Hosp 1, Changchun 130117, Peoples R China

来源：

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2023年 / 51卷 / 04期

关键词：

Pneumonia; Metabolomics; Traditional Chinese Medicine; Pneumococcus; LINOLEIC-ACID; METABOLITES; PLASMA;

D O I：

10.1016/j.cjac.2023.100234

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

To explore the potential biomarkers of QingFei Yin (QFY), a famous Chinese medicine for treating bacterial pneumonia in Northeast China, in treatment of Streptococcus pneumoniae (S. pn) pneumonia. In this study, the metabolites in the serum of healthy mice, S. pn mice, S. pn +QFY mice and S. pn + ceftriaxone mice were analyzed by Q-EXACTIVE liquid chromatography-tandem mass spectrometry. Finally, Five potential biomarkers of QFY in the treatment of S. pn pneumonia were found. There were 226 different metabolites between the S. pn and blank groups, 169 different metabolites between the S. pn and QFY groups, and 313 different metabolites between the S. pn and ceftriaxone groups. It was concluded that there were 5 pathways in the S. pn group; there were 8 pathways in the QFY group; and there were 6 pathways in the ceftriaxone group. In conclusion, The changes in arachidonic acid, phosphatidylcholine, linoleic acid, palmitic acid and oleic acid may be related to the anti-inflammatory effect of QFY. Arachidonic acid metabolism and Glycerophospholipid metabolism were related to S. pn pneumonia and ceftriaxone group. Linoleic acid metabolism was related to QFY group.

引用

页数：8

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