Hepatitis C community prevalence is over-estimated: a prospective, birth cohort study

被引：1

作者：

Mccormick, P. Aiden ^{[1
,2
]}

O'Grady, Marie ^{[1
,2
]}

De Gascun, Cillian F. ^{[3
]}

Lambert, John S. ^{[4
,5
]}

Crosbie, Orla ^{[6
,7
]}

Mckiernan, Susan ^{[8
]}

Skelly, Maeve ^{[9
]}

Holder, Paul ^{[3
]}

Courtney, Garry ^{[10
]}

Hennessy, Brian ^{[11
]}

Walsh, Kevin ^{[12
]}

Twohig, Roisin ^{[3
]}

Browne, Kate ^{[3
]}

O'Gorman, Tessa ^{[13
]}

Crowley, Vivion ^{[14
]}

Costelloe, Sean J. ^{[15
]}

O'Byrne, Roz ^{[16
]}

Whitney, Elizabeth ^{[10
]}

Gildea, Orla ^{[11
]}

Montgomery, Noreen ^{[12
]}

机构：

[1] St Vincents Univ Hosp, Natl Hepatitis Treatment Program HSE C, Liver Unit, Elm Pk,Donnybrook, Dublin 4, Ireland

[2] UCD, Elm Pk,Donnybrook, Dublin 4, Ireland

[3] UCD, Natl Virus Reference Lab, Dublin, Ireland

[4] Mater & Rotunda Hosp, Dublin, Ireland

[5] UCD, Dublin, Ireland

[6] Cork Univ Hosp, Cork, Ireland

[7] UCC, Cork, Ireland

[8] St James Hosp, Dublin, Ireland

[9] Dip Qi Univ Hosp Limerick, Limerick, Ireland

[10] St Lukes Hosp, Kilkenny, Ireland

[11] Univ Hosp Waterford, Waterford, Ireland

[12] Sligo Univ Hosp, Sligo, Ireland

[13] Mater Misericordiae Univ Hosp, Dublin, Ireland

[14] St James Univ Hosp, Dublin, Ireland

[15] Univ Hosp Cork, Cork, Ireland

[16] Univ Hosp Limerick, Limerick, Ireland

来源：

IRISH JOURNAL OF MEDICAL SCIENCE | 2024年 / 193卷 / 03期

关键词：

Birth cohort; Cirrhosis; Direct acting antiviral agents DAA's; Epidemiology; Hepatitis C;

D O I：

10.1007/s11845-023-03604-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundHepatitis C virus infection is often asymptomatic, and many patients may be unaware they are infected. Community-based, birth cohort screening has been advocated to identify these patients. It has been estimated that 0.7-1% of individuals born between 1965 and 1985 in Ireland are infected. The cost-effectiveness of screening is critically dependent on the population prevalence.AimsThe aim is to determine the community prevalence of hepatitis C virus infection in the birth cohort 1965-1985.MethodsResidual serum samples from blood tests ordered by community general practitioners were anonymised and analysed for the presence of hepatitis C antibody +/- antigen. Twelve large general hospitals throughout the country participated.ResultsA total of 14,320 samples were tested, 9347 of which were from the birth cohort 1965-1985. Seventy-two samples were positive for hepatitis C antibody of which 12 were positive for hepatitis C antigen (17%). The overall prevalence of hepatitis C antigen in the birth cohort was 0.09%. A higher prevalence (0.39%) was identified in males in two urban areas of Dublin.ConclusionsHepatitis C virus seroprevalence was much lower than previously estimated. The proportion of antibody positive patients with hepatitis C antigen was also lower than expected suggesting the effects of treatment and/or high spontaneous viral clearance. Universal birth cohort screening is unlikely to be cost-effective. Targeted birth cohort screening in high prevalence areas could be considered.

引用

页码：1257 / 1260

页数：4

共 8 条

[1] Department of Health, 2017, NCEC NATL CLIN GUIDE
[2] Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016
Garvey, P.
O'Grady, B.
Franzoni, G.
Bolger, M.
Crosby, K. Irwin
Connell, J.
Burke, D.
De Gascun, C.
Thornton, L.
[J]. EUROSURVEILLANCE, 2017, 22 (30): : 31 - 38
[3] Health Information and Quality Authority, HLTH TECHNOLOGY ASSE
[4] Health Protection Surveillance Centre, EPIDEMIOLOGY HEPATIT
[5] Global Elimination of Chronic Hepatitis
Thomas, David L.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (21) : 2041 - 2050
[6] Determination of the burden of hepatitis C virus infection in Ireland
Thornton, L.
Murphy, N.
Jones, L.
Connell, J.
Dooley, S.
Gavin, S.
Hunter, K.
Brennan, A.
[J]. EPIDEMIOLOGY AND INFECTION, 2012, 140 (08) : 1461 - 1468
[7] Natural history of hepatitis C
Westbrook, Rachel H.
Dusheiko, Geoffrey
[J]. JOURNAL OF HEPATOLOGY, 2014, 61 : S58 - S68
[8] World Health Organization, 2016, GLOBAL HLTH SECTOR S

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