Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals

被引：48

作者：

Cui, Xinyuan ^{[1
]}

Fan, Kewei ^{[2
]}

Liang, Xianghui ^{[1
]}

Gong, Wenjie ^{[3
,4
]}

Chen, Wu ^{[5
]}

He, Biao ^{[4
]}

Chen, Xiaoyuan ^{[1
]}

Wang, Hai ^{[1
]}

Wang, Xiao ^{[1
]}

Zhang, Ping ^{[1
]}

Lu, Xingbang ^{[1
]}

Chen, Rujian ^{[1
]}

Lin, Kaixiong ^{[6
]}

Liu, Jiameng ^{[1
]}

Zhai, Junqiong ^{[5
]}

Liu, Ding Xiang ^{[7
,8
]}

Shan, Fen ^{[5
]}

Li, Yuqi ^{[2
]}

Chen, Rui Ai ^{[8
]}

Meng, Huifang ^{[1
]}

Li, Xiaobing ^{[1
,2
]}

Mi, Shijiang ^{[3
,4
]}

Jiang, Jianfeng ^{[3
,4
]}

Zhou, Niu ^{[5
]}

Chen, Zujin ^{[5
]}

Zou, Jie-Jian ^{[9
]}

Ge, Deyan ^{[10
]}

Yang, Qisen ^{[10
]}

He, Kai ^{[11
]}

Chen, Tengteng ^{[6
]}

Wu, Ya-Jiang ^{[5
]}

Lu, Haoran ^{[12
]}

Irwin, David M. ^{[13
,14
]}

Shen, Xuejuan ^{[1
]}

Hu, Yuanjia ^{[1
]}

Lu, Xiaoman ^{[1
]}

Ding, Chan ^{[15
,16
]}

Guan, Yi ^{[17
,18
]}

Tu, Changchun ^{[4
,16
]}

Shen, Yongyi ^{[1
,19
]}

机构：

[1] South China Agr Univ, Coll Vet Med, Ctr Emerging & Zoonot Dis, State Key Lab Anim Dis Control & Prevent,Guangdon, Guangzhou 510642, Peoples R China

[2] Longyan Univ, Fujian Prov Key Lab Prevent & Control Anim Infect, Coll Life Sci, Longyan 364012, Peoples R China

[3] Jilin Univ, Coll Vet Med, State Key Lab Zoonot Dis, Key Lab Zoonosis Res,Minist Educ,Inst Zoonosis, Changchun 130062, Peoples R China

[4] Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130122, Peoples R China

[5] Guangzhou Zoo & Guangzhou Wildlife Res Ctr, Guangzhou 510070, Peoples R China

[6] Fujian Meihuashan Inst South China Tiger Breeding, Longyan 364201, Peoples R China

[7] South China Agr Univ, Integrat Microbiol Res Ctr, Guangzhou 510642, Guangdong, Peoples R China

[8] Guangdong Lab Lingnan Modern Agr Sci & Technol, Zhaoqing Branch Ctr, Zhaoqing 526000, Guangdong, Peoples R China

[9] Guangdong Prov Wildlife Monitoring & Rescue Ctr, Guangzhou 510000, Peoples R China

[10] Chinese Acad Sci, Inst Zool, Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China

[11] Guangzhou Univ, Sch Life Sci, Key Lab Conservat & Applicat Biodivers South Chin, Guangzhou 510006, Guangdong, Peoples R China

[12] Sun Yat Sen Univ, Sch Math, Guangzhou 510275, Peoples R China

[13] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

[14] Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON M5S 1A8, Canada

[15] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Dept Avian Infect Dis, Shanghai 201106, Peoples R China

[16] Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

[17] Shantou Univ Med Coll SUMC, Joint Influenza Res Ctr SUMC HKU, Shantou 515041, Peoples R China

[18] Univ Hong Kong, Sch Publ Hlth, Ctr Influenza Res, Hong Kong, Peoples R China

[19] Guangdong Prov Key Lab Zoonosis Prevent & Control, Guangzhou 510642, Peoples R China

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PSEUDORABIES VIRUS; GENOMIC CHARACTERIZATION; READ ALIGNMENT; CORONAVIRUS; CHINA; IDENTIFICATION; PESTIVIRUS; INFECTION; HUMANS; BATS;

D O I：

10.1038/s41467-023-38202-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wildlife is reservoir of emerging viruses. Here we identified 27 families of mammalian viruses from 1981 wild animals and 194 zoo animals collected from south China between 2015 and 2022, isolated and characterized the pathogenicity of eight viruses. Bats harbor high diversity of coronaviruses, picornaviruses and astroviruses, and a potentially novel genus of Bornaviridae. In addition to the reported SARSr-CoV-2 andHKU4-CoV-like viruses, picornavirus and respiroviruses also likely circulate between bats and pangolins. Pikas harbor a new clade of Embecovirus and a new genus of arenaviruses. Further, the potential cross-species transmission of RNA viruses (paramyxovirus and astrovirus) and DNA viruses (pseudorabies virus, porcine circovirus 2, porcine circovirus 3 and parvovirus) between wildlife and domestic animals was identified, complicating wildlife protection and the prevention and control of these diseases in domestic animals. This study provides a nuanced view of the frequency of host-jumping events, as well as assessments of zoonotic risk.

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