Biopolymer-Based Nanogel Approach in Drug Delivery: Basic Concept and Current Developments

被引：41

作者：

Altuntas, Ebru ^{[1
]}

Ozkan, Burcu ^{[2
]}

Gungor, Sevgi ^{[1
]}

Ozsoy, Yildiz ^{[1
]}

机构：

[1] Istanbul Univ, Fac Pharm, Dept Pharmaceut Technol, TR-34116 Istanbul, Turkiye

[2] Yildiz Tech Univ, Grad Sch Nat & Appl Sci, TR-34220 Istanbul, Turkiye

来源：

PHARMACEUTICS | 2023年 / 15卷 / 06期

关键词：

biopolymers; nanogels; drug delivery; polysaccharide-based nanogels; protein-based nanogels; nanotechnology; SELF-ASSEMBLED NANOGEL; HYALURONIC-ACID; INTRACELLULAR DELIVERY; IN-VITRO; HYDROGEL NANOPARTICLES; CHITOSAN NANOPARTICLES; CHONDROITIN SULFATE; CROSS-LINKING; BIOMEDICAL APPLICATIONS; RESPONSIVE HYDROGELS;

D O I：

10.3390/pharmaceutics15061644

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Due to their increased surface area, extent of swelling and active substance-loading capacity and flexibility, nanogels made from natural and synthetic polymers have gained significant interest in scientific and industrial areas. In particular, the customized design and implementation of nontoxic, biocompatible, and biodegradable micro/nano carriers makes their usage very feasible for a range of biomedical applications, including drug delivery, tissue engineering, and bioimaging. The design and application methodologies of nanogels are outlined in this review. Additionally, the most recent advancements in nanogel biomedical applications are discussed, with particular emphasis on applications for the delivery of drugs and biomolecules.

引用

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