Advancements in understanding the molecular and immune mechanisms of Bartonella pathogenicity

被引：17
作者：
Jin, Xiaoxia [1 ,2 ]
Gou, Yuze [3 ]
Xin, Yuxian [3 ]
Li, Jingwei [1 ,2 ]
Sun, Jingrong [3 ]
Li, Tingting [1 ,2 ]
Feng, Jie [3 ,4 ]
机构：
[1] Lanzhou Univ, Gansu Prov Key Lab Evidence Based Med & Clin Trans, Lanzhou, Peoples R China
[2] Lanzhou Univ, Lanzhou Ctr TB Res, Sch Basic Med Sci, Lanzhou, Peoples R China
[3] Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou, Peoples R China
[4] Lanzhou Univ, Coll Vet Med, State Key Lab Vet Etiol Biol, Lanzhou, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2023年 / 14卷
基金：
英国科研创新办公室;
关键词：
Bartonella; blood-sucking arthropods; endothelial cells; erythrocytes; antibody; immune escape; CAT-SCRATCH DISEASE; LOCUS-B IALB; EXPERIMENTAL-INFECTION; ENDOTHELIAL-CELLS; EFFECTOR PROTEINS; DOMESTIC CATS; HENSELAE; QUINTANA; BACILLIFORMIS; ADHESIN;
D O I：
10.3389/fmicb.2023.1196700
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Bartonellae are considered to be emerging opportunistic pathogens. The bacteria are transmitted by blood-sucking arthropods, and their hosts are a wide range of mammals including humans. After a protective barrier breach in mammals, Bartonella colonizes endothelial cells (ECs), enters the bloodstream, and infects erythrocytes. Current research primarily focuses on investigating the interaction between Bartonella and ECs and erythrocytes, with recent attention also paid to immune-related aspects. Various molecules related to Bartonella's pathogenicity have been identified. The present review aims to provide a comprehensive overview of the newly described molecular and immune responses associated with Bartonella's pathogenicity.
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页数：12
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