Sex differences in associations between APOE ε2 and longitudinal cognitive decline

被引：9

作者：

Wood, Madeline E. ^{[1
]}

Xiong, Lisa Y. ^{[1
]}

Wong, Yuen Yan ^{[1
]}

Buckley, Rachel F. ^{[1
]}

Swardfager, Walter ^{[1
]}

Masellis, Mario ^{[1
]}

Lim, Andrew S. P. ^{[1
]}

Nichols, Emma ^{[1
]}

La Joie, Renaud ^{[1
]}

Casaletto, Kaitlin B. ^{[1
]}

Kumar, Raj G. ^{[1
]}

Dams-O'Connor, Kristen ^{[1
]}

Palta, Priya ^{[1
]}

George, Kristen M. ^{[1
]}

Satizabal, Claudia L. ^{[1
]}

Barnes, Lisa L. ^{[1
]}

Schneider, Julie A. ^{[1
]}

Binet, Alexa Pichette ^{[1
]}

Villeneuve, Sylvia ^{[1
]}

Pa, Judy ^{[1
]}

Brickman, Adam E. ^{[1
]}

Black, Sandra S. ^{[1
]}

Rabin, Jennifer S. ^{[1
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Room M6-178,2075 Bayview Ave, Toronto, ON M4N 3M5, Canada

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 10期

基金：

加拿大健康研究院;

关键词：

Alzheimer's disease; APOE; cognitive decline; race; ethnicity; sex differences; APOLIPOPROTEIN-E GENOTYPE; ALZHEIMERS-DISEASE; APOE EPSILON-4; RISK; DEMENTIA; BLACK; AGE; IMPAIRMENT; MECHANISMS; ALLELE;

D O I：

10.1002/alz.13036

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTIONWe examined whether sex modifies the association between APOE epsilon 2 and cognitive decline in two independent samples. METHODSWe used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (epsilon 2 or epsilon 4 carrier vs. epsilon 3/epsilon 3) and sex on cognitive decline in NHW and NHB participants separately. RESULTSIn both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE epsilon 2 and cognitive decline in NHW participants. Specifically, relative to APOE epsilon 3/epsilon 3, APOE epsilon 2 protected against cognitive decline in men but not women. Among APOE epsilon 2 carriers, men had slower decline than women. Among APOE epsilon 3/epsilon 3 carriers, cognitive trajectories did not differ between sexes. There were no sex-specific associations of APOE epsilon 2 with cognition in NHB participants (N = 2010). DISCUSSIONIn NHW adults, APOE epsilon 2 may protect men but not women against cognitive decline. HighlightsWe studied sex-specific apolipoprotein E (APOE) epsilon 2 effects on cognitive decline.In non-Hispanic White (NHW) adults, APOE epsilon 2 selectively protects men against decline.Among men, APOE epsilon 2 was more protective than APOE epsilon 3/epsilon 3.In women, APOE epsilon 2 was no more protective than APOE epsilon 3/epsilon 3.Among APOE epsilon 2 carriers, men had slower decline than women.There were no sex-specific APOE epsilon 2 effects in non-Hispanic Black (NHB) adults.

引用

页码：4651 / 4661

页数：11

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