Oxidative stress: The nexus of obesity and cognitive dysfunction in diabetes

被引：42
作者：
Li, Huimin [1 ]
Ren, Jing [1 ,2 ]
Li, Yusi [1 ]
Wu, Qian [1 ]
Wei, Junping [1 ]
机构：
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
[2] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
oxidative stress; obesity; cognitive dysfunction in diabetes; reactive oxygen species; insulin resistance; neuroinflammation; lipid metabolism disorders; BRAIN INSULIN-RESISTANCE; AMYLOID-BETA-PEPTIDE; NF-KAPPA-B; MITOCHONDRIAL DYSFUNCTION; ALZHEIMERS-DISEASE; ADIPOSE-TISSUE; TRANSCRIPTION FACTORS; LIPOCALIN; METABOLISM; INFLAMMATION;
D O I：
10.3389/fendo.2023.1134025
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity has been associated with oxidative stress. Obese patients are at increased risk for diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative stress, and diabetic cognitive dysfunction. Obesity can induce the biological process of oxidative stress by disrupting the adipose microenvironment (adipocytes, macrophages), mediating low-grade chronic inflammation, and mitochondrial dysfunction (mitochondrial division, fusion). Furthermore, oxidative stress can be implicated in insulin resistance, inflammation in neural tissues, and lipid metabolism disorders, affecting cognitive dysfunction in diabetics.
引用
收藏
页数：13
相关论文
共 182 条
  • [11] Alzheimer disease risk genes 29 and counting
    Bertram, Lars
    Tanzi, Rudolph E.
    [J]. NATURE REVIEWS NEUROLOGY, 2019, 15 (04) : 191 - 192
  • [12] Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies
    Bhatti, Jasvinder Singh
    Bhatti, Gurjit Kaur
    Reddy, P. Hemachandra
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (05): : 1066 - 1077
  • [13] Risk of dementia in diabetes mellitus: a systematic review
    Biessels, GJ
    Staekenborg, S
    Brunner, E
    Brayne, C
    Scheltens, P
    [J]. LANCET NEUROLOGY, 2006, 5 (01) : 64 - 74
  • [14] Obesity: global epidemiology and pathogenesis
    Blueher, Matthias
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2019, 15 (05) : 288 - 298
  • [15] ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53
    Bockmann, J
    Kreutz, MR
    Gundelfinger, ED
    Böckers, TM
    [J]. JOURNAL OF NEUROCHEMISTRY, 2002, 83 (04) : 1013 - 1017
  • [16] Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease
    Bourgonje, Arno R.
    Feelisch, Martin
    Faber, Klaas Nico
    Pasch, Andreas
    Dijkstra, Gerard
    van Goor, Harry
    [J]. TRENDS IN MOLECULAR MEDICINE, 2020, 26 (11) : 1034 - 1046
  • [17] Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling
    Brand, Martin D.
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2016, 100 : 14 - 31
  • [18] Simultaneous Mass Spectrometry-Based Apolipoprotein Profiling and Apolipoprotein E Phenotyping in Patients with ASCVD and Mild Cognitive Impairment
    Brkovic, Ilijana Begcevic
    Zohrer, Benedikt
    Scholz, Markus
    Reinicke, Madlen
    Dittrich, Julia
    Kamalsada, Surab
    Baber, Ronny
    Beutner, Frank
    Teren, Andrej
    Engel, Christoph
    Wirkner, Kerstin
    Thiele, Holger
    Loeffler, Markus
    Riedel-Heller, Steffi G.
    Ceglarek, Uta
    [J]. NUTRIENTS, 2022, 14 (12)
  • [19] Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain
    Butterfield, D. Allan
    Di Domenico, Fabio
    Barone, Eugenio
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2014, 1842 (09): : 1693 - 1706
  • [20] Butterfield DA, 2002, NEUROBIOL AGING, V23, P655
12345678910