Oxidative stress: The nexus of obesity and cognitive dysfunction in diabetes

被引：42
作者：
Li, Huimin [1 ]
Ren, Jing [1 ,2 ]
Li, Yusi [1 ]
Wu, Qian [1 ]
Wei, Junping [1 ]
机构：
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
[2] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
oxidative stress; obesity; cognitive dysfunction in diabetes; reactive oxygen species; insulin resistance; neuroinflammation; lipid metabolism disorders; BRAIN INSULIN-RESISTANCE; AMYLOID-BETA-PEPTIDE; NF-KAPPA-B; MITOCHONDRIAL DYSFUNCTION; ALZHEIMERS-DISEASE; ADIPOSE-TISSUE; TRANSCRIPTION FACTORS; LIPOCALIN; METABOLISM; INFLAMMATION;
D O I：
10.3389/fendo.2023.1134025
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity has been associated with oxidative stress. Obese patients are at increased risk for diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative stress, and diabetic cognitive dysfunction. Obesity can induce the biological process of oxidative stress by disrupting the adipose microenvironment (adipocytes, macrophages), mediating low-grade chronic inflammation, and mitochondrial dysfunction (mitochondrial division, fusion). Furthermore, oxidative stress can be implicated in insulin resistance, inflammation in neural tissues, and lipid metabolism disorders, affecting cognitive dysfunction in diabetics.
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页数：13
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  • [1] Health Effects of Overweight and Obesity in 195 Countries over 25 Years
    Afshin, Ashkan
    Forouzanfar, Mohammad H.
    Reitsma, Marissa B.
    Sur, Patrick
    Estep, Kara
    Lee, Alex
    Marczak, Laurie
    Mokdad, Ali H.
    Moradi-Lakeh, Maziar
    Naghavi, Mohsen
    Salama, Joseph S.
    Vos, Theo
    Abate, Kalkidan H.
    Abbafati, Cristiana
    Ahmed, Muktar B.
    Al-Aly, Ziyad
    Alkerwi, Ala'a
    Al-Raddadi, Rajaa
    Amare, Azmeraw T.
    Amberbir, Alemayehu
    Amegah, Adeladza K.
    Amini, Erfan
    Amrock, Stephen M.
    Anjana, Ranjit M.
    Arnlov, Johan
    Asayesh, Hamid
    Banerjee, Amitava
    Barac, Aleksandra
    Baye, Estifanos
    Bennett, Derrick A.
    Beyene, Addisu S.
    Biadgilign, Sibhatu
    Biryukov, Stan
    Bjertness, Espen
    Boneya, Dube J.
    Campos-Nonato, Ismael
    Carrero, Juan J.
    Cecilio, Pedro
    Cercy, Kelly
    Ciobanu, Liliana G.
    Cornaby, Leslie
    Damtew, Solomon A.
    Dandona, Lalit
    Dandona, Rakhi
    Dharmaratne, Samath D.
    Duncan, Bruce B.
    Eshrati, Babak
    Esteghamati, Alireza
    Feigin, Valery L.
    Fernandes, Joao C.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (01) : 13 - 27
  • [2] Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia
    Agrawal, Ishan
    Jha, Sushmita
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
  • [3] Lipocalin-2: Structure, function, distribution and role in metabolic disorders
    Al Jaberi, Saeeda
    Cohen, Athena
    Abdulrazzaq, Yousef M.
    Ojha, Shreesh
    Bastaki, Salim
    Adeghate, Ernest A.
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2021, 142
  • [4] Quantitative assessment of FDG uptake in brown fat using standardized uptake value and dual-time-point scanning
    Alkhawaldeh, Khaled
    Alavi, Abass
    [J]. CLINICAL NUCLEAR MEDICINE, 2008, 33 (10) : 663 - 667
  • [5] Mitochondrial metabolism of reactive oxygen species
    Andreyev, AI
    Kushnareva, YE
    Starkov, AA
    [J]. BIOCHEMISTRY-MOSCOW, 2005, 70 (02) : 200 - 214
  • [6] Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
    Arnold, Steven E.
    Arvanitakis, Zoe
    Macauley-Rambach, Shannon L.
    Koenig, Aaron M.
    Wang, Hoau-Yan
    Ahima, Rexford S.
    Craft, Suzanne
    Gandy, Sam
    Buettner, Christoph
    Stoeckel, Luke E.
    Holtzman, David M.
    Nathan, David M.
    [J]. NATURE REVIEWS NEUROLOGY, 2018, 14 (03) : 168 - 181
  • [7] The pathways of mitophagy for quality control and clearance of mitochondria
    Ashrafi, G.
    Schwarz, T. L.
    [J]. CELL DEATH AND DIFFERENTIATION, 2013, 20 (01) : 31 - 42
  • [8] NF-κB, Inflammation, and Metabolic Disease
    Baker, Rebecca G.
    Hayden, Matthew S.
    Ghosh, Sankar
    [J]. CELL METABOLISM, 2011, 13 (01) : 11 - 22
  • [9] Oxidative stress and expression of insulin signaling proteins in the brain of diabetic rats: Role of Nigella sativa oil and antidiabetic drugs
    Balbaa, Mahmoud
    Abdulmalek, Shaymaa A.
    Khalil, Sofia
    [J]. PLOS ONE, 2017, 12 (05):
  • [10] The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease
    Barone, Eugenio
    Di Domenico, Fabio
    Perluigi, Marzia
    Butterfield, D. Allan
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2021, 176 : 16 - 33
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