Sarcoma Patients Admitted to the Intensive Care Unit (ICU): Predictive Relevance of Common Sepsis and Performance Parameters

被引：0
作者：
Striefler, Jana K. [1 ,2 ,3 ,4 ,5 ]
Binder, Phung T. [2 ,3 ,4 ,5 ]
Brandes, Franziska [2 ,3 ,4 ,5 ]
Rau, Daniel [3 ,4 ,5 ,6 ]
Wittenberg, Silvan [3 ,4 ,5 ,6 ]
Kaul, David [3 ,4 ,5 ,7 ]
Roohani, Siyer [3 ,4 ,5 ,7 ]
Jarosch, Armin [3 ,4 ,5 ,8 ]
Schaefer, Frederik M. [3 ,4 ,5 ,9 ]
Oellinger, Robert [3 ,4 ,5 ,10 ]
Maerdian, Sven [3 ,4 ,5 ,6 ]
Bullinger, Lars [2 ,3 ,4 ,5 ,11 ,12 ]
Eckardt, Kai -Uwe [3 ,4 ,5 ,13 ]
Kruse, Jan [3 ,4 ,5 ,13 ]
Floercken, Anne [2 ,3 ,4 ,5 ,11 ,12 ]
机构：
[1] Univ Med Ctr Hamburg Eppendorf, Dept Internal Med 2, Oncol Hematol BMT Pneumol, Hamburg, Germany
[2] Charite Univ Med Berlin, Dept Hematol Oncol & Tumor Immunol, Berlin, Germany
[3] Free Univ Berlin, Berlin, Germany
[4] Humboldt Univ, Berlin, Germany
[5] Berlin Inst Hlth, Berlin, Germany
[6] Charite Univ Med Berlin, Ctr Musculoskeletal Surg, Campus Virchow Klinikum, Berlin, Germany
[7] Charite Univ Med Berlin, Dept Radiat Oncol, Campus Virchow Klinikum, Berlin, Germany
[8] Charite Univ Med Berlin, Inst Pathol, Campus Mitte, Berlin, Germany
[9] Charite Univ Med Berlin, Dept Radiol, Berlin, Germany
[10] Charite Univ Med Berlin, Dept Surg, Campus Virchow Klinikum, Berlin, Germany
[11] German Canc Consortium DKTK, Partner Site Berlin, Heidelberg, Baden Wurttembe, Germany
[12] German Canc Res Ctr, Heidelberg, Baden Wurttembe, Germany
[13] Charite Univ Med Berlin, Dept Nephrol & Med Intens Care, Campus Virchow Klinikum, Berlin, Germany
来源：
CANCER MANAGEMENT AND RESEARCH | 2023年 / 15卷
关键词：
soft tissue sarcoma; intensive care unit; sepsis and performance scores; SOFA; SAPS II; ICU-specific survival; SOFT-TISSUE SARCOMA; SAPS-II; EPIDEMIOLOGY;
D O I：
10.2147/CMAR.S400430
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: Prognosis of sarcoma patients is improving, with a better understanding of sarcomagenesis revealing novel therapeutic targets. However, aggressive chemotherapy remains an essential part of treatment, bearing the risk of severe side effects that require intensive medical treatment. Available data on the characteristics and clinical outcome of sarcoma patients admitted to intensive care units (ICU) are sparse. Patients and Methods: We performed a retrospective analysis of sarcoma patients admitted to the ICU from 2005 to 2022. Patients >= 18 years with histologically proven sarcoma were included in our study. Results: Sixty-six patients were eligible for analysis. The following characteristics had significant impact on overall survival: sex (p=0.046), tumour localization (p=0.02), therapeutic intention (p=0.02), line of chemotherapy (p<0.001), SAPS II score (p=0.03) and SOFA score (p=0.02). Conclusion: Our study confirms the predictive relevance of established sepsis and performance scores in sarcoma patients. For overall survival, common clinical characteristics are also of significant value. Further investigation is needed to optimize ICU treatment of sarcoma patients.
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收藏
页码：321 / 334
页数：14
相关论文
共 38 条
  • [1] Outcomes of Patients with Malignancy Admitted to the Intensive Care Units: A Prospective Study
    Assi, Hazem I.
    Halim, Nour Abdul
    Alameh, Ibrahim
    Khoury, Jessica
    Nahra, Vicky
    Sukhon, Fares
    Charafeddine, Maya
    El Nakib, Clara
    Moukalled, Nour
    Bou Zerdan, Maroun
    Bou Khalil, Pierre
    [J]. CRITICAL CARE RESEARCH AND PRACTICE, 2021, 2021
  • [2] Outcomes in elderly patients admitted to the intensive care unit with solid tumors
    Auclin, Edouard
    Charles-Nelson, Anais
    Abbar, Baptiste
    Guerot, Emmanuel
    Oudard, Stephane
    Hauw-Berlemont, Caroline
    Thibault, Constance
    Monnier, Alexandra
    Diehl, Jean-Luc
    Katsahian, Sandrine
    Fagon, Jean-Yves
    Taieb, Julien
    Aissaoui, Nadia
    [J]. ANNALS OF INTENSIVE CARE, 2017, 7
  • [3] Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs)
    Barth, C.
    Soares, M.
    Toffart, A. C.
    Timsit, J. F.
    Burghi, G.
    Irrazaba, C.
    Pattison, N.
    Tobar, E.
    Almeida, B. F.
    Silva, U., V
    Azevedo, L. C.
    Rabbat, A.
    Lamer, C.
    Parrot, A.
    Souza-Dantas, V. C.
    Wallet, F.
    Blot, F.
    Bourdin, G.
    Piras, C.
    Delemazure, J.
    Durand, M.
    Salluh, J.
    Azoulay, E.
    Lemiale, Virginie
    [J]. ANNALS OF INTENSIVE CARE, 2018, 8
  • [4] Validation of severity scoring systems SAPS II and APACHE II in a single-center population
    Capuzzo, M
    Valpondi, V
    Sgarbi, A
    Bortolazzi, S
    Pavoni, V
    Gilli, G
    Candini, G
    Gritti, G
    Alvisi, R
    [J]. INTENSIVE CARE MEDICINE, 2000, 26 (12) : 1779 - 1785
  • [5] Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up (vol 29, pg 51, 2018)
    Casali, P. G.
    Abecassis, N.
    Aro, H. T.
    Bauer, S.
    Biagini, R.
    Bielack, S.
    Bonvalot, S.
    Boukovinas, I.
    Bovee, J. V. M. G.
    Brodovvicz, T.
    Broto, J. M.
    Buonadonna, A.
    De Alava, E.
    Tos, A. P. Dei
    Del Muro, X. G.
    Dileo, P.
    Eriksson, M.
    Fedenko, A.
    Ferraresi, V.
    Ferrari, A.
    Ferrari, S.
    Frezza, A. M.
    Gasperoni, S.
    Gelderblom, H.
    Gil, T.
    Grignani, G.
    Gronchi, A.
    Haas, R. L.
    Hassan, B.
    Hohenberger, P.
    Lssels, R.
    Joensuu, H.
    Jones, R. L.
    Judson, I.
    Jutte, P.
    Kaal, S.
    Kasper, B.
    Kopeckova, K.
    Krakorova, D. A.
    Le Cesne, A.
    Lugowska, I.
    Merimsky, O.
    Montemurro, M.
    Pantaleo, M. A.
    Piana, R.
    Picci, P.
    Piperno-Neumann, S.
    Pousa, A. L.
    Reichardt, P.
    Robinson, M. H.
    [J]. ANNALS OF ONCOLOGY, 2018, 29 : 268 - 269
  • [6] Critically ill patients with cancer: A clinical perspective
    Daniel Martos-Benitez, Frank
    de Dios Soler-Morejon, Caridad
    Ximena Lara-Ponce, Karla
    Orama-Requejo, Versis
    Burgos-Araguez, Daile
    Larrondo-Muguercia, Hilev
    Lespoir, Rahim W.
    [J]. WORLD JOURNAL OF CLINICAL ONCOLOGY, 2020, 11 (10): : 809 - 835
  • [7] Gender Differences in Treatment Allocation and Survival of Advanced Gastroesophageal Cancer: A Population-Based Study
    Dijksterhuis, Willemieke P. M.
    Kalff, Marianne C.
    Wagner, Anna D.
    Verhoeven, Rob H. A.
    Lemmens, Valery E. P. P.
    van Oijen, Martijn G. H.
    Gisbertz, Suzanne S.
    Henegouwen, Mark I. van Berge
    van Laarhoven, Hanneke W. M.
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021, 113 (11): : 1551 - 1560
  • [8] Dyk D., 2001, Intensivmedizin und Notfallmedizin, V38, P479, DOI 10.1007/s003900170045
  • [9] Oncological patients in the intensive care unit: prognosis, decision-making, therapies and end-of-life care
    Ewelina, Biskup
    Cai Fengfeng
    Marcus, Vetter
    Stephan, Marsch
    [J]. SWISS MEDICAL WEEKLY, 2017, 147
  • [10] Prognosis of patients with haematological malignancies admitted to the intensive care unit: Sequential Organ Failure Assessment (SOFA) trend is a powerful predictor of mortality
    Geerse, Daniel A.
    Span, Lambert F. R.
    Pinto-Sietsma, Sara-joan
    van Mook, Walther N. K. A.
    [J]. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2011, 22 (01) : 57 - 61
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