Characterization of thymol derivatives from Eupatorium fortunei Turcz. aerial parts

被引：4

作者：

Nguyen-Ngoc, Hieu ^{[1
]}

Trang, Bui Thi Thu ^{[2
]}

Thu, Do Thi Hoai ^{[3
]}

Nguyen, Huu Tung ^{[1
]}

Hoang, Vu Dinh ^{[4
]}

Tran, Quang De ^{[5
]}

Nguyen, Tuan Ngoc ^{[6
]}

Quang, Dang Ngoc ^{[7
]}

Pham, Giang Nam ^{[8
]}

Le Dang, Quang ^{[9
,10
]}

机构：

[1] PHENIKAA Univ, Fac Pharm, Hanoi, Vietnam

[2] Hanoi Univ Ind, Fac Chem Technol, Hanoi, Vietnam

[3] Vietnam Acad Sci & Technol VAST, Ctr High Technol Dev, Hanoi, Vietnam

[4] Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam

[5] Can Tho Univ, Coll Nat Sci, Dept Chem, Can Tho, Vietnam

[6] Ind Univ Ho Chi Minh City, Inst Biotechnol & Food Technol, Ho Chi Minh, Vietnam

[7] Hanoi Natl Univ Educ, Fac Chem, Hanoi, Vietnam

[8] Univ Cote Azur, Nice Inst Chem, Nice, France

[9] VAST, Inst Trop Technol, Hanoi, Vietnam

[10] Grad Univ Sci & Technol, VAST, Hanoi, Vietnam

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 13期

关键词：

Eupatorium fortunei; thymol derivatives; alpha-glucosidase; acetylcholinesterase;

D O I：

10.1080/14786419.2023.2172726

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

From the aerial parts of Eupatorium fortunei, four thymol derivatives (1-4) were isolated and structurally elucidated by NMR and mass spectroscopic methods. Of which, a new dimeric thymol derivative (1) was characterized and its absolute configuration was established by electronic circular dichroism quantum method. In addition, the 1D and 2D NMR as well as HR-ESI mass spectral data of 2 were provided for the first time. Compounds 2-4 were evaluated for their inhibitory activity against alpha-glucosidase and acetylcholinesterase enzymes. All tested compounds showed weak inhibition at the concentration range of 1-256 mu g/mL in both enzymatic assays.

引用

页码：2306 / 2312

页数：7

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