Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer

被引：54

作者：

Bhat, Asif Ahmad ^{[1
]}

Goyal, Ahsas ^{[2
]}

Thapa, Riya ^{[1
]}

Almalki, Waleed Hassan ^{[3
]}

Kazmi, Imran ^{[4
]}

Alzarea, Sami I. ^{[5
]}

Singh, Mahaveer ^{[6
]}

Rohilla, Suman ^{[7
]}

Saini, Tarun Kumar ^{[8
]}

Kukreti, Neelima ^{[9
]}

Meenakshi, Dhanalekshmi Unnikrishnan ^{[10
]}

Fuloria, Neeraj Kumar ^{[11
]}

Sekar, Mahendran ^{[12
]}

Gupta, Gaurav ^{[13
]}

机构：

[1] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur 302017, India

[2] GLA Univ, Inst Pharmaceut Res, Mathura, UP, India

[3] Umm Al Qura Univ, Coll Pharm, Dept Pharmacol, Mecca, Saudi Arabia

[4] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia

[5] Jouf Univ, Coll Pharm, Dept Pharmacol, Sakaka, Al Jouf, Saudi Arabia

[6] Swami Keshvanand Inst Pharm SKIP, Bikaner 334022, India

[7] Shree Guru Gobind Singh Tricentenary Univ, SGT Coll Pharm, Gurugram 122505, India

[8] New Delhi Govt NCT Delhi, Lok Nayak Hosp, Dept Neurosurg ICU, New Delhi, India

[9] Graph Era Hill Univ, Sch Pharm, Dehra Dun 248007, India

[10] Natl Univ Sci & Technol, Coll Pharm, Muscat 130, Oman

[11] AIMST Univ, Fac Pharm, Kedah 08100, Malaysia

[12] Monash Univ Malaysia, Sch Pharm, Bandar Sunway, Subang Jaya 47500, Selangor, Malaysia

[13] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll, Ctr Global Hlth Res, Chennai, India

来源：

CYTOKINE | 2023年 / 171卷

关键词：

IFN-gamma signaling; Type; 2; immunity; Cytokines; T-helper; Cancer; OVARIAN-CANCER; IFN-GAMMA; BREAST-CANCER; LUNG-CANCER; PSEUDOMONAS EXOTOXIN; ANTITUMOR-ACTIVITY; RADIATION-THERAPY; TREATMENT OPTIONS; CELLS; EPIDEMIOLOGY;

D O I：

10.1016/j.cyto.2023.156376

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer involves cells' abnormal growth and ability to invade or metastasize to different body parts. Cancerous cells can divide uncontrollably and spread to other areas through the lymphatic or circulatory systems. Tumors form when malignant cells clump together in an uncontrolled manner. In this context, the cytokine interferongamma (IFN-gamma) is crucial in regulating immunological responses, particularly malignancy. While IFN-gamma is wellknown for its potent anti-tumor effects by activating type 1 immunity, recent research has revealed its ability to suppress type 2 immunity, associated with allergy and inflammatory responses. This review aims to elucidate the intricate function of IFN-gamma in inhibiting type 2 immune responses to cancer. We explore how IFN-gamma influences the development and function of immune cells involved in type 2 immunity, such as mast cells, eosinophils, and T-helper 2 (Th2) cells. Additionally, we investigate the impact of IFN-mediated reduction of type 2 immunity on tumor development, metastasis, and the response to immunotherapeutic interventions. To develop successful cancer immunotherapies, it is crucial to comprehend the complex interplay between type 2 and type 1 immune response and the regulatory role of IFN-gamma. This understanding holds tremendous promise for the development of innovative treatment approaches that harness the abilities of both immune response types to combat cancer. However, unraveling the intricate interplay between IFN-gamma and type 2 immunity in the tumor microenvironment will be essential for achieving this goal.

引用

页数：14

共 124 条

[111] MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer [J].