Palladium-catalyzed Sonogashira coupling to synthesis of gem-difluoroenynes

被引：1

作者：

Li, Lin ^{[1
]}

Mei, Yan ^{[1
]}

Zhang, Junlei ^{[1
]}

He, Kehan ^{[1
,2
]}

Pan, Fei ^{[1
]}

机构：

[1] Sichuan Normal Univ, Coll Chem & Mat Sci, 5 Jingan Rd, Chengdu 610068, Peoples R China

[2] Xichang Univ, Sch Sci, 1 Xuefu Rd, Xichang 615000, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2023年 / 268卷

基金：

中国国家自然科学基金;

关键词：

gem-difluoroenyne; Palladium; Copper; Sonogashira; Cross-coupling reaction; STEREOSELECTIVE-SYNTHESIS; TERMINAL ALKYNES; ARYLBORONIC ACIDS; FLUORINE; ROUTE; DIFLUOROVINYLATION; TOSYLATES; FACILE; ENYNES;

D O I：

10.1016/j.jfluchem.2023.110111

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Herein, we developed the palladium-catalyzed Sonogashira-type cross-coupling of 1-bromo-2,2-difluoroethylene with a variety of aromatic and aliphatic terminal alkynes proceeds smoothly at mild reaction condition to access the corresponding gem-difluoroenyne derivatives. 1-Bromo-2,2-difluoroethylene is a useful difluoroethenyl source because of its commercially available and easy-to-handle. This new synthetic protocol provided a novel strategy to directly construct gem-difluoroenynes with good functional group tolerance and high yields.

引用

页数：8

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