Association between prevalence of laxative use and history of bone fractures and cardiovascular diseases in patients with chronic kidney disease: the Fukuoka Kidney disease Registry (FKR) study

被引：3

作者：

Yamada, Shunsuke ^{[1
]}

Tanaka, Shigeru ^{[1
]}

Arase, Hokuto ^{[1
]}

Hiyamuta, Hiroto ^{[1
]}

Kitamura, Hiromasa ^{[1
]}

Tokumoto, Masanori ^{[2
]}

Mitsuiki, Koji ^{[3
]}

Tsuruya, Kazuhiko ^{[4
]}

Kitazono, Takanari ^{[1
]}

Nakano, Toshiaki ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[2] Japanese Red Cross Fukuoka Hosp, Div Nephrol, Fukuoka, Japan

[3] Harasanshin Hosp, Div Nephrol, Fukuoka, Japan

[4] Nara Med Univ, Dept Nephrol, Nara, Japan

来源：

CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2023年 / 27卷 / 02期

关键词：

Bone fracture; Cardiovascular disease; Chronic kidney disease; Constipation; Laxative; INDOXYL SULFATE; DOUBLE-BLIND; CONSTIPATION; DYSFUNCTION; ACTIVATION; KREMEZIN; DEATH; RISK; AXIS;

D O I：

10.1007/s10157-022-02289-8

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background Constipation is a common complication in patients with chronic kidney disease (CKD) and is involved in the pathogenesis of dysbiosis and progression of CKD. However, little is known about its association with disorders of the bone-cardiovascular axis in patients with CKD. Methods We performed a cross-sectional analysis of 3878 patients with CKD using the baseline dataset of the Fukuoka Kidney disease Registry study, as a multicenter, prospective cohort study of pre-dialysis CKD patients. The main exposure of interest was constipation defined as use of at least one type of laxative. The main outcomes were the histories of bone fractures and cardiovascular diseases (CVDs) as manifestations of disorders of the bone-cardiovascular axis. Results The prevalences of laxative use and histories of bone fractures and CVDs increased as kidney function declined. Among the 3878 patients, 532 (13.7%) patients used laxatives, 235 (6.1%) patients had prior bone fractures, and 1001 (25.8%) patients had prior CVDs. Histories of bone fractures and CVDs were significantly more prevalent among laxative users (P < 0.05). Multivariable-adjusted logistic regression analysis revealed that patients with laxatives had a significantly higher odds ratios for histories of bone fractures and CVDs than those without laxatives [adjusted odds ratios (95% confidence intervals) 1.67 (1.20-2.31) and 1.70 (1.30-2.22), respectively, P < 0.05]. Conclusions These results suggest that constipation indicated by laxative use is associated with increased prevalences of historical bone fractures and CVDs in pre-dialysis patients with CKD.

引用

页码：151 / 160

页数：10

共 49 条

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