Volumetric brain correlates of gait associated with cognitive decline in community-dwelling older adults

被引：4

作者：

Poole, Victoria N. ^{[1
,2
]}

Oveisgharan, Shahram ^{[1
,3
]}

Yu, Lei ^{[1
,3
]}

Dawe, Robert J. ^{[1
,4
]}

Leurgans, Sue E. ^{[1
,3
,5
]}

Zhang, Shengwei ^{[1
]}

Arfanakis, Konstantinos ^{[1
,4
]}

Buchman, Aron S. ^{[1
,3
]}

Bennett, David A. ^{[1
,3
]}

机构：

[1] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[2] Rush Univ, Med Ctr, Dept Orthoped Surg, Chicago, IL 60612 USA

[3] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[4] Rush Univ, Med Ctr, Dept Diagnost Radiol & Nucl Med, Chicago, IL 60612 USA

[5] Rush Univ, Dept Family & Prevent Med, Med Ctr, Chicago, IL USA

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2023年 / 15卷

基金：

美国国家卫生研究院;

关键词：

older adults; gait speed; cognitive decline; attention; executive functioning; memory; MRI; brain volumes; RUSH MEMORY; SPEED; PERFORMANCE; IMPAIRMENT; NUTRITION; WALKING;

D O I：

10.3389/fnagi.2023.1194986

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: To determine the extent to which the regional brain volumes associated with slow gait speed can inform subsequent cognitive decline in older adults from the Rush Memory and Aging Project.Approach: We utilized deformation-based morphometry (DBM) in a whole-brain exploratory approach to identify the regional brain volumes associated with gait speed assessed over a short distance during an in-home assessment. We created deformation scores to summarize the gait-associated regions and entered the scores into a series of longitudinal mixed effects models to determine the extent to which deformation predicted change in cognition over time, controlling for associations between gait and cognition.Results: In 438 older adults (81 +/- 7; 76% female), DBM revealed that slower gait speed was associated with smaller volumes across frontal white matter, temporal grey matter, and subcortical areas and larger volumes in the ventricles during the same testing cycle. When a subset was followed over multiple (5 +/- 2) years, slower gait speed was also associated with annual declines in global cognition, executive functioning, and memory abilities. Several of the gait-related brain structures were associated with these declines in cognition; however, larger ventricles and smaller medial temporal lobe volumes proved most robust and attenuated the association between slow gait and cognitive decline.Conclusion: Regional brain volumes in the ventricles and temporal lobe associated with both slow gait speed and faster cognitive decline have potential to improve risk stratification for cognitive decline in older adults.

引用

页数：8

共 47 条

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