Development and Antidiabetic Activity Study of Repaglinide Loaded Self-nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery

The goal of the current work was to create and describe a self-nano emulsifying drug de-livery system containing Repaglinide to improve the oral absorption of the drug by enhancing its solubility and dissolution rate. When put into the aqueous phase while being gently stirred, isotropic combinations of oil, surfactant, co-surfactant, and medicament in SNEDDS create an oil-in-water emulsion. Repaglinide is an oral hypoglycemic medication that was investigated for solubility in oils, surfactants, and co-surfactants. Pseudo-ternary phase diagrams were made to pinpoint the self-micro emulsion region. Triacetin, Tween 80 with PEG 400 being mixed in different ratios to develop five different SNEDDS formulations. Upon diluting the optimum formulation with water, the self-emulsification characteristics, zeta potential and droplet size had been investigated. Studies on in-vitro drug dissolution were conducted and analyzed with pure drugs. The results revealed that drug dissolution was substantially more rapid and extensive than with pure drugs. The findings of this study show the possible application of SNEDDS for enhancing solubility, dissolution, and bioavailability. When compared to pure medication, in vivo research showed that SNEDDS effectively re-duced blood glucose levels. The findings of this investigation point to the possibility of using a newly designed SNEDDS formulation to deliver the poorly water-soluble medication repaglinide.