Gender Differences in the Prevalence of Parkinson's Disease

被引：36
作者：
Zirra, Alexandra [1 ]
Rao, Shilpa C. [2 ,3 ]
Bestwick, Jonathan [1 ]
Rajalingam, Rajasumi [4 ]
Marras, Connie [4 ]
Blauwendraat, Cornelis [5 ]
Mata, Ignacio [2 ,3 ]
Noyce, Alastair J. [1 ,6 ]
机构：
[1] Queen Mary Univ London, Wolfson Inst Populat Hlth, Prevent Neurol Unit, London EC1M 6BQ, England
[2] Cleveland Clin Fdn, Lerner Res Inst, Genom Med Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA
[3] Case Western Reserve Univ, Dept Mol Med, Cleveland, OH 44106 USA
[4] Univ Toronto, Univ Hlth Network, Toronto, ON, Canada
[5] NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
[6] UCL Inst Neurol, Dept Clin & Movement Neurosci, London, England
来源：
MOVEMENT DISORDERS CLINICAL PRACTICE | 2023年 / 10卷 / 01期
关键词：
Parkinson's disease; meta-analysis; systematic review; prevalence; gender differences; TO-DOOR SURVEY; NATIONAL-HEALTH; RISK; POPULATION; EPIDEMIOLOGY; DISORDERS; CHINESE; CONSUMPTION; SMOKING; AGE;
D O I：
10.1002/mdc3.13584
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background Parkinson's disease (PD) affects males more than females. The reasons for the gender differences in PD prevalence remain unclear. Objective The objective of this systematic review and meta-analysis was to update the overall male/female prevalence ratios (OPR). Methods We updated previous work by searching MEDLINE, SCOPUS, and OVID for articles reporting PD prevalence for both genders between 2011 and 2021. We calculated OPRs and investigated heterogeneity in effect estimates. Results We included 19 new articles and 13 articles from a previously published meta-analysis. The OPR was 1.18, 95% CI, [1.03, 1.36]. The OPR was lowest in Asia and appeared to be decreasing over time. Study design, national wealth, and participant age did not explain OPR heterogeneity. Conclusion Gender differences in PD prevalence may not be as stark as previously thought. Studies are needed to understand the role of other determinants of gender differences in PD prevalence.
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页码：86 / 93
页数：8
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