Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays

被引：130

作者：

Ashton, Nicholas J. ^{[1
,2
,3
,4
,5
]}

Puig-Pijoan, Albert ^{[6
,7
,8
]}

Mila-Aloma, Marta ^{[7
,9
,10
,11
]}

Fernandez-Lebrero, Aida ^{[6
,7
,9
]}

Garcia-Escobar, Greta ^{[6
]}

Gonzalez-Ortiz, Fernando ^{[1
,9
]}

Kac, Przemyslaw R. ^{[1
]}

Brum, Wagner S. ^{[1
,12
]}

Benedet, Andrea L. ^{[1
]}

Lantero-Rodriguez, Juan ^{[1
]}

Day, Theresa A. ^{[13
]}

Vanbrabant, Jeroen ^{[14
]}

Stoops, Erik ^{[14
]}

Vanmechelen, Eugeen ^{[14
]}

Triana-Baltzer, Gallen ^{[15
]}

Moughadam, Setareh ^{[15
]}

Kolb, Hartmuth ^{[15
]}

Ortiz-Romero, Paula ^{[7
,9
]}

Karikari, Thomas K. ^{[1
,16
]}

Minguillon, Carolina ^{[7
,9
,11
]}

Sanchez, Juan Jose Hernandez ^{[17
]}

Navalpotro-Gomez, Irene ^{[6
,7
,9
]}

Grau-Rivera, Oriol ^{[6
,7
,9
,11
]}

Manero, Rosa Maria ^{[6
,7
]}

Puente-Periz, Victor ^{[6
,7
]}

de la Torre, Rafael ^{[7
,18
,19
]}

Roquer, Jaume ^{[6
,7
,8
]}

Dage, Jeff L. ^{[20
]}

Zetterberg, Henrik ^{[1
,21
,22
,23
,24
]}

Blennow, Kaj ^{[1
,21
]}

Suarez-Calvet, Marc ^{[6
,7
,9
,11
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, SE-43180 Gothenburg, Sweden

[2] Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Inst Neurosci & Physiol, Dept Psychiat & Neurochem,Sahlgrenska Acad, Gothenburg, Sweden

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Maurice Wohl Clin Neurosci Inst, London, England

[4] South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr Mental Hlth, London, England

[5] South London & Maudsley NHS Fdn, Biomed Res Unit Dementia, London, England

[6] Hosp Mar, Neurol Dept, Cognit Decline & Movement Disorders Unit, Barcelona, Spain

[7] IMIM Hosp Mar Med Res Inst, Barcelona, Spain

[8] Univ Autonoma Barcelona, Dept Med, Barcelona, Spain

[9] Pasqual Maragall Fdn, Barcelona Beta Brain Res Ctr BBRC, Barcelona, Spain

[10] Univ Pompeu Fabra, Barcelona, Spain

[11] Ctr Invest Biomed Red Fragilidad & Envejecimiento, Madrid, Spain

[12] Univ Fed Rio Grande Sul UFRGS, Grad Program Biol Sci Biochem, Porto Alegre, RS, Brazil

[13] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

[14] ADx NeuroSci, Technol Pk 94, Ghent, Belgium

[15] Neurosci Biomarkers Janssen Res & Dev, La Jolla, CA USA

[16] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[17] Lab Referencia Catalunya, Barcelona, Spain

[18] Univ Pompeu Fabra, Dept Expt & Hlth Sci, CEXS UPF, Barcelona, Spain

[19] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain

[20] Indiana Univ Sch Med, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA

[21] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[22] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England

[23] UCL, UK Dementia Res Inst, London, England

[24] Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 05期

基金：

瑞典研究理事会; 欧洲研究理事会; 美国国家卫生研究院; 欧盟地平线“2020”;

关键词：

biomarker; dementia; disease; phosphorylated tau; plasma; tau; ALZHEIMERS-DISEASE; PERFORMANCE;

D O I：

10.1002/alz.12841

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Direct comparisons of the main blood phosphorylated tau immunoassays in memory clinic populations are needed to understand possible differences. Methods In the BIODEGMAR study, 197 participants presenting with cognitive complaints were classified into an Alzheimer's disease (AD) or a non-AD cerebrospinal fluid (CSF) profile group, according to their amyloid beta 42/ phosphorylated tau (A beta 42/p-tau) ratio. We performed a head-to-head comparison of nine plasma and nine CSF tau immunoassays and determined their accuracy to discriminate abnormal CSF A beta 42/p-tau ratio. Results All studied plasma tau biomarkers were significantly higher in the AD CSF profile group compared to the non-AD CSF profile group and significantly discriminated abnormal CSF A beta 42/p-tau ratio. For plasma p-tau biomarkers, the higher discrimination accuracy was shown by Janssen p-tau217 (r = 0.76; area under the curve [AUC] = 0.96), ADx p-tau181 (r = 0.73; AUC = 0.94), and Lilly p-tau217 (r = 0.73; AUC = 0.94). Discussion Several plasma p-tau biomarkers can be used in a specialized memory clinic as a stand-alone biomarker to detect biologically-defined AD. Highlights Patients with an Alzheimer's disease cerebrospinal fluid (AD CSF) profile have higher plasma phosphorylated tau (p-tau) levels than the non-AD CSF profile group. All plasma p-tau biomarkers significantly discriminate patients with an AD CSF profile from the non-AD CSF profile group. Janssen p-tau217, ADx p-tau181, and Lilly p-tau217 in plasma show the highest accuracy to detect biologically defined AD. Janssen p-tau217, ADx p-tau181, Lilly p-tau217, Lilly p-tau181, and UGot p-tau231 in plasma show performances that are comparable to their CSF counterparts.

引用

页码：1913 / 1924

页数：12

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