The Association between Red Meat Consumption and Advanced Colorectal Adenomas in a Population Undergoing a Screening-Related Colonoscopy in Alberta, Canada

被引:2
作者
Farah, Eliya [1 ,2 ]
Hutchinson, John M. [1 ,2 ]
Ruan, Yibing [2 ,3 ]
O'Sullivan, Dylan E. [1 ,2 ,3 ]
Hilsden, Robert J. [2 ,4 ,5 ]
Brenner, Darren R. [1 ,2 ,3 ]
机构
[1] Univ Calgary, Cumming Sch Med, Dept Oncol, Calgary, AB T2N 4N1, Canada
[2] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB T2N 4N1, Canada
[3] Canc Care Alberta, Dept Canc Epidemiol & Prevent Res, Calgary, AB T2N 4N1, Canada
[4] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB T2N 4N1, Canada
[5] Forzani & MacPhail Colon Canc Screening Ctr, Alberta Hlth Serv, Calgary, AB T2N 4Z6, Canada
关键词
processed red meat; unprocessed red meat; risk factor; advanced colorectal adenomas; colorectal cancer; PROCESSED MEAT; PHYSICAL-ACTIVITY; UNPROCESSED RED; COOKING METHODS; CANCER; RISK; QUESTIONNAIRE;
D O I
10.3390/cancers16030495
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Simple Summary In this study, we examined whether different types of red meat, processed and unprocessed, contribute to the development of advanced colorectal adenomas, which can be precursors to cancer. Through examining the diets of 1083 individuals at their initial colonoscopy in Calgary, we assessed the impact of meat intake on the presence of these early cancer indicators. We observed that the total amount of red and processed meat, but not unprocessed meat, was associated with the presence of advanced colorectal adenomas at the time of a screening colonoscopy. Our observations provide preliminary evidence that may contribute to a nuanced understanding of diet's role in colorectal health.Abstract The association between red meat consumption and colorectal cancer has been rigorously examined. However, a more comprehensive understanding of how the intake of unprocessed red meat contributes to the development of early precancerous colorectal lesions, such as advanced colorectal adenomas (ACRAs), requires further investigation. We examined the associations between different types of red meat intake and ACRAs in a sample population of 1083 individuals aged >= 50 years undergoing an initial screening colonoscopy in Calgary, Alberta, Canada. Associations between grams per day of total, processed, and unprocessed red meat from diet history questionnaires and ACRAs were evaluated with multivariable logistic regression models. We also applied cubic spline models fitted with three knots (10th, 50th, and 90th percentiles) to identify potential nonlinear associations. We did not observe a meaningful association between unprocessed red meat intake and the presence of ACRAs. In contrast, for every 10 g/d increase in total and processed meat intake, we observed an increase in the odds of ACRAs at the screening colonoscopy (adjusted odds ratio (OR) = 1.05, 95% [CI = 1.01-1.09], p = 0.04) and (adjusted OR = 1.11, 95% [CI = 1.02-1.20], p = 0.02), respectively. This study highlights the importance of differentiating between types of red meat consumption in the context of dietary risks associated with ACRAs.
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页数:11
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