Tertiary lymphoid structures in autoimmune diseases

被引：6

作者：

Dong, Yuanji ^{[1
]}

Wang, Ting ^{[2
]}

Wu, Huaxiang ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Dept Rheumatol, Sch Med, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Thorac Dis Ctr,Dept Resp Dis, Hangzhou, Zhejiang, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 14卷

关键词：

tertiary lymphoid structures; autoimmune disease; fibroblasts; immune cells; potential target; LYMPHOTOXIN-BETA-RECEPTOR; PRIMARY SJOGRENS-SYNDROME; NONOBESE DIABETIC MICE; ROR-GAMMA-T; B-CELLS; IGG4-RELATED DACRYOADENITIS; RHEUMATOID-ARTHRITIS; GERMINAL-CENTERS; CD45(+)CD4(+)CD3(-) CELLS; VIRUS-INFECTION;

D O I：

10.3389/fimmu.2023.1322035

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tertiary lymphoid structures (TLSs) are organized lymphoid-like aggregations in non-lymphoid tissues. Tissues with chronic and persistent inflammation infiltration may drive and form ectopic germinal center-like structures, which are very common in autoimmune diseases, chronic infections, and tumor microenvironments. However, the mechanisms governing the formation of TLSs are still being explored. At present, it is not clear whether the formation of TLSs is associated with local uncontrolled immune inflammatory responses. While TLSs suggest a good prognosis in tumors, the opposite is true in autoimmune diseases. This review article will discuss the current views on initiating and maintaining TLSs and the potential therapeutic target in autoimmune diseases.

引用

页数：11

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