Synthesis and Properties of Ag-Au Alloy Nanoparticles with Controlled Composition for Computed Tomography Imaging Applications

被引:2
|
作者
Linh, Nguyen Thi Ngoc [1 ]
Tam, Le The [2 ]
Du, Nguyen Hoa [2 ]
Vinh, Nguyen Dinh [1 ]
Tuyet, Phan Thi Hong [2 ]
Quy, Bui Minh [1 ]
An, Cao Thu [3 ]
Suong, Nguyen Thi [2 ]
Hoa, Nguyen Thi Hong [1 ]
Lu, Le Trong [4 ,5 ]
机构
[1] Thai Nguyen Univ, Thai Nguyen Univ Sci, Fac Chem, Tan Thinh Ward, Thai Nguyen City, Vietnam
[2] Vinh Univ, Sch Chem Biol & Environm, 182 Le Duan, Vinh City 43000, Nghean, Vietnam
[3] Vinh Univ, High Sch Gifted, 182 Le Duan, Vinh City, Nghean, Vietnam
[4] Vietnam Acad Sci & Technol, Inst Trop Technol, 18 Hoang Quoc Viet Rd, Hanoi, Vietnam
[5] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol, 18 Hoang Quoc Viet Rd, Hanoi, Vietnam
关键词
Ag-Au alloy; CT imaging applications; poly (maleic anhydride-alt-1-octadecene) (PMAO); thermal decomposition; X-ray attenuation property; COLLOIDAL GOLD NANOPARTICLES; SILVER NANOPARTICLES; CONTRAST AGENTS; BIODISTRIBUTION; GROWTH; SIZE;
D O I
10.1002/cnma.202300619
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Numerous non-invasive assays have been developed to support CT imaging, consequently increasing the precision of diagnosis. Although these efforts made a significant contribution to clinical research, there is still more to be done. The goal is to replace conventional contrast agents with more potent ones. In this study, Ag-Au alloy nanoparticles were fabricated by substitution method between the precursor Au3+ and the previously prepared Ag nanoparticles. Effects of Au3+ quantity on the formation and characteristics of Ag-Au alloy nanoparticles were investigated. It showed that Ag-Au nanoalloy with a size of 14.2 +/- 1.0 nm, SPR absorption peak at 520 nm, and Ag: Au atomic ratio of approximately 3 : 1 were appropriate for biomedical applications. After phase transfer using poly (maleic anhydride-alt-1-octadecene) (PMAO), the nano Ag-Au solution owned remarkable durability, stability and non-toxicity Vero healthy cell line at high test concentration. In-vitro CT imaging demonstrated a good X-ray adsorption coefficient, and the hounsfield units (HU) was noticeably increased. As a promising CT contrast agent, the X-ray attenuation of nano Ag-Au solutions correlated linearly with concentrations. These findings led to a potential application in the biomedical field, particularly in computed tomography (CT) imaging diagnosis. In this study, Ag-Au alloy NPs were synthesized successfully in an organic solvent. The quantity of HAuCl4.3H2O influenced the morphology and properties of the alloy materials. The Ag-Au solutions after phase transfer using poly (maleic anhydride-alt-1-octadecene) reached high durability, stability and non-toxic to the Vero healthy cell line. In-vitro CT images indicated a good X-ray absorption coefficient. Our findings expanded the potential uses of Ag-Au alloy NPs in biomedicine, particularly for imaging diagnosis employing CT imaging technology.image
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页数:11
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