Understanding Islet Autoantibodies in Prediction of Type 1 Diabetes

被引：7
作者：
Jia, Xiaofan [1 ,2 ]
Yu, Liping [1 ]
机构：
[1] Univ Colorado, Sch Med, Barbara Davis Ctr Diabet, Aurora, CO 80045 USA
[2] Univ Colorado, Barbara Davis Ctr Diabet, Sch Med, 1775 Aurora Ct B140, Aurora, CO 80045 USA
来源：
JOURNAL OF THE ENDOCRINE SOCIETY | 2023年 / 8卷 / 01期
关键词：
islet autoantibody; type; 1; diabetes; prediction; antibody assay; PROTEIN-TYROSINE-PHOSPHATASE; INSULIN-DEPENDENT DIABETICS; IDENTIFY HIGH-RISK; HUMAN T-CELLS; ELECTROCHEMILUMINESCENCE ASSAYS; GENERAL-POPULATION; CHILDREN; PROGRESSION; ANTIBODIES; AFFINITY;
D O I：
10.1210/jendso/bvad160
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
As screening studies and preventive interventions for type 1 diabetes (T1D) advance rapidly, the utility of islet autoantibodies (IAbs) in T1D prediction comes with challenges for early and accurate disease progression prediction. Refining features of IAbs can provide more accurate risk assessment. The advances in islet autoantibodies assay techniques help to screen out islet autoantibodies with high efficiency and high disease specificity. Exploring new islet autoantibodies to neoepitopes/neoantigens remains a hot research field for improving prediction and disease pathogenesis. We will review the recent research progresses of islet autoantibodies to better understand the utility of islet autoantibodies in prediction of T1D.
引用
收藏
页数：8
相关论文
共 90 条
  • [1] Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development
    Acevedo-Calado, Maria
    James, Eddie A.
    Morran, Michael P.
    Pietropaolo, Susan L.
    Ouyang, Qin
    Arribas-Layton, David
    Songini, Marco
    Liguori, Marco
    Casu, Anna
    Auchus, Richard J.
    Huang, Shuai
    Yu, Liping
    Michels, Aaron
    Gianani, Roberto
    Pietropaolo, Massimo
    [J]. DIABETES CARE, 2017, 40 (04) : 561 - 568
  • [2] Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes
    Acevedo-Calado, Maria J.
    Pietropaolo, Susan L.
    Morran, Michael P.
    Schnell, Santiago
    Vonberg, Andrew D.
    Verge, Charles F.
    Gianani, Roberto
    Becker, Dorothy J.
    Huang, Shuai
    Greenbaum, Carla J.
    Yu, Liping
    Davidson, Howard W.
    Michels, Aaron W.
    Rich, Stephen S.
    Pietropaolo, Massimo
    [J]. DIABETES, 2019, 68 (09) : 1819 - 1829
  • [3] Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    Achenbach, P
    Koczwara, K
    Knopff, A
    Naserke, H
    Ziegler, AG
    Bonifacio, E
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (04) : 589 - 597
  • [4] Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12
    Achenbach, Peter
    Hawa, Mohammed I.
    Krause, Stephanie
    Lampasona, Vito
    Jerram, Samuel T.
    Williams, Alistair J. K.
    Bonifacio, Ezio
    Ziegler, Anette G.
    Leslie, R. David
    [J]. DIABETOLOGIA, 2018, 61 (07) : 1644 - 1649
  • [5] Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01
    Arribas-Layton, David
    Guyer, Perrin
    Delong, Thomas
    Dang, Mylinh
    Chow, I-Ting
    Speake, Cate
    Greenbaum, Carla J.
    Kwok, William W.
    Baker, Rocky L.
    Haskins, Kathryn
    James, Eddie A.
    [J]. DIABETES, 2020, 69 (07) : 1492 - 1502
  • [6] Hybrid insulin peptides are neo-epitopes for CD4 T cells in autoimmune diabetes
    Baker, Rocky L.
    Jamison, Braxton L.
    Haskins, Kathryn
    [J]. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2019, 26 (04) : 195 - 200
  • [7] Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles
    Balke, Else M.
    Balti, Eric V.
    Van der Auwera, Bart
    Weets, Ilse
    Costa, Olivier
    Demeester, Simke
    Abrams, Pascale
    Casteels, Kristina
    Coeckelberghs, Marina
    Tenoutasse, Sylvie
    Keymeulen, Bart
    Pipeleers, Daniel G.
    Gorus, Frans K.
    [J]. DIABETES CARE, 2018, 41 (05) : 1076 - 1083
  • [8] DIABETES IN IDENTICAL-TWINS - A STUDY OF 200 PAIRS
    BARNETT, AH
    EFF, C
    LESLIE, RDG
    PYKE, DA
    [J]. DIABETOLOGIA, 1981, 20 (02) : 87 - 93
  • [9] New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
    Bender, Christine
    Rajendran, Sakthi
    von Herrath, Matthias G.
    [J]. FRONTIERS IN ENDOCRINOLOGY, 2021, 11
  • [10] The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 diabetes
    Bingley, Polly J.
    Boulware, David C.
    Krischer, Jeffrey P.
    [J]. DIABETOLOGIA, 2016, 59 (03) : 542 - 549
123456789