Hyaluronic acid-modified and verteporfin-loaded polylactic acid nanogels promote scarless wound healing by accelerating wound re-epithelialization and controlling scar formation

被引:12
作者
Chen, Kun [1 ]
Liu, Yuanhu [2 ,3 ]
Liu, Xiaohui [2 ]
Guo, Yongli [4 ]
Liu, Jing [1 ]
Ding, Jiaojiao [2 ]
Zhang, Zheng [5 ]
Ni, Xin [2 ,4 ]
Chen, Yunsheng [6 ]
机构
[1] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Burn & Plast Surg, Beijing 100045, Peoples R China
[2] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Otolaryngol, Beijing 100045, Peoples R China
[3] Beijing Childrens Hosp, Shunyi Maternal & Childrens Hosp, Beijing, Peoples R China
[4] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Natl Ctr Childrens Hlth,Beijing Key Lab Pediat Dis, Beijing 100045, Peoples R China
[5] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
[6] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Burn,Shanghai Burn Inst, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
基金
中国国家自然科学基金;
关键词
Hyaluronic acid; Polylactic acid nanoparticles; Scarless wound healing; Verteporfin; Yes-associated protein; LACTATE;
D O I
10.1186/s12951-023-02014-x
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Wound healing is a common occurrence. However, delayed healing and aberrant scarring result in pathological wound healing. Accordingly, a scarless wound healing remains a significant clinical challenge. In this study, we constructed hyaluronic acid (HA)-modified and verteporfin (VP)-loaded polylactic acid (PLA) nanogels (HA/VP-PLA) to promote scarless wound healing by accelerating wound re-epithelialization and controlling scar formation. Owing to the unique structure of HA incorporating and coating in VP-loaded PLA nanoparticles, HA/VP-PLA could be topically applied on wound to achieve targeted delivery to fibroblasts. Then, HA/VP-PLA released HA and lactic acid (LA) to stimulate the proliferation and migration of fibroblasts, as well as VP to inhibit Yes-associated protein (YAP) expression and nuclear localization to suppress fibrosis. In vitro (skin fibroblasts) and in vivo (rat and rabbit models) experiments strongly suggested that HA/VP-PLA promoted scarless wound healing by accelerating wound re-epithelialization and controlling scar formation. Therefore, our work provides a feasible strategy for scarless wound healing, and the sophisticated HA/VP-PLA exhibit a great potential for clinical applications.
引用
收藏
页数:10
相关论文
共 37 条
  • [1] Smart Dressings for Wound Healing: A Review
    Almeida, Isabella Barros
    Barretto Teixeira, Luciana Garcez
    de Carvalho, Fernanda Oliveira
    Silva, Erika Ramos
    Nunes, Paula Santos
    Viana dos Santos, Marcio Roberto
    de Souza Araujo, Adriano Antunes
    [J]. ADVANCES IN SKIN & WOUND CARE, 2021, 34 (02) : 1 - 8
  • [2] Alsamman S, 2020, SCI TRANSL MED, P12
  • [3] Nanocomposites as biomolecules delivery agents in nanomedicine
    Bamburowicz-Klimkowska, Magdalena
    Poplawska, Magdalena
    Grudzinski, Ireneusz P.
    [J]. JOURNAL OF NANOBIOTECHNOLOGY, 2019, 17 (1)
  • [4] Aspects of Nanomaterials in Wound Healing
    Chakrabarti, Srijita
    Chattopadhyay, Pronobesh
    Islam, Johirul
    Ray, Subhabrata
    Raju, Pakalapati Srinivas
    Mazumder, Bhaskar
    [J]. CURRENT DRUG DELIVERY, 2019, 16 (01) : 26 - 41
  • [5] Synergistic transdermal delivery of nanoethosomes embedded in hyaluronic acid nanogels for enhancing photodynamic therapy
    Chen, Yunsheng
    Zhang, Zheng
    Xin, Yu
    Zhou, Rong
    Jiang, Kai
    Sun, Xiyang
    He, Dannong
    Song, Jie
    Zhang, Yixin
    [J]. NANOSCALE, 2020, 12 (28) : 15435 - 15442
  • [6] Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms
    Da Costa, David
    Exbrayat-Heritier, Chloe
    Rambaud, Basile
    Megy, Simon
    Terreux, Raphael
    Verrier, Bernard
    Primard, Charlotte
    [J]. JOURNAL OF NANOBIOTECHNOLOGY, 2021, 19 (01)
  • [7] Advances in modified hyaluronic acid-based hydrogels for skin wound healing
    Ding, Yan-Wen
    Wang, Ze-Yu
    Ren, Zi-Wei
    Zhang, Xu-Wei
    Wei, Dai-Xu
    [J]. BIOMATERIALS SCIENCE, 2022, 10 (13) : 3393 - 3409
  • [8] Template-oriented synthesis of hydroxyapatite nanoplates for 3D bone printing
    Doustkhah, Esmail
    Zare, Reza Najafi
    Yamauchi, Yusuke
    Taheri-Kafrani, Asghar
    Mohtasham, Hamed
    Esmat, Mohamed
    Ide, Yusuke
    Fukata, Naoki
    Rostamnia, Sadegh
    Sadeghi, Morteza H.
    Assadi, M. Hussein N.
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (45) : 7228 - 7234
  • [9] Wound repair and regeneration: Mechanisms, signaling, and translation
    Eming, Sabine A.
    Martin, Paul
    Tomic-Canic, Marjana
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (265)
  • [10] A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing
    Gong, ChangYang
    Wu, QinJie
    Wang, YuJun
    Zhang, DouDou
    Luo, Feng
    Zhao, Xia
    Wei, YuQuan
    Qian, ZhiYong
    [J]. BIOMATERIALS, 2013, 34 (27) : 6377 - 6387