New ruthenium(II) complexes with cyclic thio- and semicarbazone: evaluation of cytotoxicity and effects on cell migration and apoptosis of lung cancer cells

被引:1
作者
Goncalves, Yasmim G. [1 ,2 ]
Becceneri, Amanda B. [2 ]
Graminha, Angelica E. [2 ,7 ]
Miranda, Victor M. [3 ]
Rios, Rafaella R. [2 ]
Rinaldi-Neto, Francisco [2 ]
Costa, Monica S. [4 ]
Goncalves, Ana C. R. [5 ]
Deflon, Victor M. [2 ]
Yoneyama, Kelly A. G. [4 ]
Maia, Pedro I. S. [5 ]
Franca, Eduardo F. [6 ]
Cominetti, Marcia R. [7 ]
Silva, Roberto S. [2 ]
Von Poelhsitz, Gustavo [1 ]
机构
[1] Univ Fed Uberlandia, Chem Inst, Uberlandia, MG, Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci, Lab Fotoquim & Quim Bioinorgan, Ribeirao Preto, SP, Brazil
[3] Univ Sao Paulo, Chem Inst Sao Carlos, Grp Quim Inorgan Estrut & Biol, USP Sao Carlos, Sao Carlos, SP, Brazil
[4] Univ Fed Uberlandia, Genet & Biochem Inst, Uberlandia, MG, Brazil
[5] Univ Fed Triangulo Mineiro, Exacts Nat Sci & Educ Inst, Uberaba, MG, Brazil
[6] Univ Fed Uberlandia, Chem Inst, Lab Cristalog & Quim Computac, Uberlandia, MG, Brazil
[7] Univ Fed Sao Carlos, Gerontol Dept, Sao Carlos, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
IN-VITRO; CYTOSKELETON; LIGANDS; THIOSEMICARBAZONES; ARREST;
D O I
10.1039/d3dt00750b
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
We describe the synthesis, physicochemical characterization, and in vitro antitumor assays of four novel analogous ruthenium(II) complexes with general formula cis-[Ru-II(N-L)(P-P)(2)]PF6, where P-P = bis(diphenylphosphine)methane (dppm, in complexes 1 and 2) or bis(diphenylphosphine)ethane (dppe, in complexes 3 and 4) and N-L = 5,6-diphenyl-4,5-dihydro-2H-[1,2,4]triazine-3-thione (Btsc, in complexes 1 and 3) or 5,6-diphenyltriazine-3-one (Bsc, in complexes 2 and 4). The data were consistent with cis arrangement of the biphosphine ligands. For the Btsc and Bsc ligands, the data pointed to monoanionic bidentate coordination to ruthenium(II) through N,S and N,O, respectively. Single-crystal X-ray diffraction showed that complex 1 crystallized in the monoclinic system, space group P2(1)/c. Determination of the cytotoxicity profiles of complexes 1-4 gave SI values ranging from 1.19 to 3.50 against the human lung adenocarcinoma cell line A549 and the non-tumor lung cell line MRC-5. Although the molecular docking studies suggested that the interaction between DNA and complex 4 was energetically favorable, the experimental results showed that they interacted weakly. Overall, our results demonstrated that these novel ruthenium(II) complexes have interesting in vitro antitumor potential and this study may contribute to further studies in medicinal inorganic chemistry.
引用
收藏
页码:9590 / 9606
页数:17
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