Rh(iii)-catalyzed C-H activation/annulation of N-carbamoylindoles with CF3-imidoyl sulfoxonium ylides for the divergent synthesis of trifluoromethyl-substituted (dihydro)pyrimidoindolones

被引：24

作者：

Duan, Yubo ^{[1
]}

Lu, Shu-Ning ^{[1
]}

Yang, Zuguang ^{[1
]}

Chen, Zhengkai ^{[1
]}

Wu, Xiao-Feng ^{[2
,3
]}

机构：

[1] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Key Lab Surface & Interface Sci Polymer Mat Zhejia, Hangzhou 310018, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China

[3] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 15期

关键词：

INDOLE ALKALOIDS; ANNULATION; ACTIVATION; FLUORINE; ALKYNES;

D O I：

10.1039/d3qo00803g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and straightforward strategy for the divergent synthesis of trifluoromethyl-substituted (dihydro)pyrimidoindolones via Rh(iii)-catalyzed C-H activation/annulation of N-carbamoylindoles with CF3-imidoyl sulfoxonium ylides has been achieved. The cascade reaction might proceed through a C-H imidoylmethylation, tautomerization and intramolecular nucleophilic addition sequence. A wide range of functionalized pyrimidoindolone derivatives were constructed in good to excellent yields under redox-neutral conditions.

引用

收藏

页码：3843 / 3848

页数：6

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