Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine

被引：3

作者：

de Malliard, Isabelle ^{[1
,7
]}

Houist, Anne-Laure ^{[1
]}

Peytavin, Gilles ^{[2
,3
]}

L'Yavanc, Thomas ^{[4
]}

Bouvier, Magali ^{[5
]}

Cappy, Pierre ^{[5
]}

Lelievre, Jean-Daniel ^{[1
,6
]}

Feredj, Elsa ^{[1
]}

Vindrios, William ^{[1
]}

Gallien, Sebastien ^{[1
]}

Melica, Giovanna ^{[1
]}

机构：

[1] Henri Mondor Hosp, Assistance Publ Hop Paris, Dept Clin Immunol & Infect Dis, Creteil, France

[2] Univ Paris, Infect Antimicrobials Modelling Evolut, Inserm, Paris, France

[3] Hop Bichat Claude Bernard, Assistance Publ Hop Paris, Lab Pharmacol Toxicol, Paris, France

[4] Hop Jean Jaures, Posthospitalizat & Rehabil Unit, Paris, France

[5] Henri Mondor Hosp, Dept Virol, Creteil, France

[6] Univ Paris Est Creteil, Vaccine Res Inst, Inserm Equipe 16 U955, Creteil, France

[7] Henri Mondor Hosp, Assistance Publ Hop Paris, Dept Clin Immunol & Infect Dis, 51 Ave Marechal Lattre Tassigny, F-94010 Creteil, France

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 05期

关键词：

adipocyte trapping; gynecoid fat distribution; HIV infection; intramuscular long-acting antiretroviral drugs; virological failure; HIV;

D O I：

10.1093/ofid/ofad217

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index <30 kg/m(2).

引用

页数：3

共 12 条

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