Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine

被引：4

作者：

de Malliard, Isabelle ^{[1
,7
]}

Houist, Anne-Laure ^{[1
]}

Peytavin, Gilles ^{[2
,3
]}

L'Yavanc, Thomas ^{[4
]}

Bouvier, Magali ^{[5
]}

Cappy, Pierre ^{[5
]}

Lelievre, Jean-Daniel ^{[1
,6
]}

Feredj, Elsa ^{[1
]}

Vindrios, William ^{[1
]}

Gallien, Sebastien ^{[1
]}

Melica, Giovanna ^{[1
]}

机构：

[1] Henri Mondor Hosp, Assistance Publ Hop Paris, Dept Clin Immunol & Infect Dis, Creteil, France

[2] Univ Paris, Infect Antimicrobials Modelling Evolut, Inserm, Paris, France

[3] Hop Bichat Claude Bernard, Assistance Publ Hop Paris, Lab Pharmacol Toxicol, Paris, France

[4] Hop Jean Jaures, Posthospitalizat & Rehabil Unit, Paris, France

[5] Henri Mondor Hosp, Dept Virol, Creteil, France

[6] Univ Paris Est Creteil, Vaccine Res Inst, Inserm Equipe 16 U955, Creteil, France

[7] Henri Mondor Hosp, Assistance Publ Hop Paris, Dept Clin Immunol & Infect Dis, 51 Ave Marechal Lattre Tassigny, F-94010 Creteil, France

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 05期

关键词：

adipocyte trapping; gynecoid fat distribution; HIV infection; intramuscular long-acting antiretroviral drugs; virological failure; HIV;

D O I：

10.1093/ofid/ofad217

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index <30 kg/m(2).

引用

页数：3

共 12 条

[1] Intramuscular injections into the buttocks: Are they truly intramuscular? [J].

Chan, V. O. ;

Colville, J. ;

Persaud, T. ;

Buckley, O. ;

Hamilton, S. ;

Torreggiani, W. C. .

EUROPEAN JOURNAL OF RADIOLOGY, 2006, 58 (03) :480-484

[2] Exploring predictors of HIV-1 virologic failure to long-acting cabotegravir and rilpivirine: a multivariable analysis [J].

Cutrell, Amy G. ;

Schapiro, Jonathan M. ;

Perno, Carlo F. ;

Kuritzkes, Daniel R. ;

Quercia, Romina ;

Patel, Parul ;

Polli, Joseph W. ;

Dorey, David ;

Wang, Yongwei ;

Wu, Sterling ;

Van Eygen, Veerle ;

Crauwels, Herta ;

Ford, Susan L. ;

Baker, Mark ;

Talarico, Christine L. ;

St Clair, Marty ;

Jeffrey, Jerry ;

White, C. Thomas ;

Vanveggel, Simon ;

Vandermeulen, Kati ;

Margolis, David A. ;

Aboud, Michael ;

Spreen, William R. ;

van Lunzen, Jan .

AIDS, 2021, 35 (09) :1333-1342

[3] HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy [J].

Dupin, N ;

Buffet, M ;

Marcelin, AG ;

Lamotte, C ;

Gorin, I ;

Ait-Arkoub, Z ;

Tréluyer, JM ;

Bui, P ;

Calvez, V ;

Peytavin, G .

AIDS, 2002, 16 (18) :2419-2424

[4]

Han K, 2022, 24 INT AIDS C JUL 29

[5] Pharmacokinetics and Drug-Drug Interactions of Long-Acting Intramuscular Cabotegravir and Rilpivirine [J].

Hodge, Daryl ;

Back, David J. ;

Gibbons, Sara ;

Khoo, Saye H. ;

Marzolini, Catia .

CLINICAL PHARMACOKINETICS, 2021, 60 (07) :835-853

[6] A Compartmental Pharmacokinetic Evaluation of Long-Acting Rilpivirine in HIV-Negative Volunteers for Pre-Exposure Prophylaxis [J].

Jackson, A. G. A. ;

Else, L. J. ;

Mesquita, P. M. M. ;

Egan, D. ;

Back, D. J. ;

Karolia, Z. ;

Ringner-Nackter, L. ;

Higgs, C. J. ;

Herold, B. C. ;

Gazzard, B. G. ;

Boffito, M. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 96 (03) :314-323

[7] Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection [J].

Orkin, Chloe O. C. ;

Arasteh, Keikawus A. K. ;

Hernandez-Mora, M. Gorgolas M. G. H. M. ;

Pokrovsky, Vadim P. V. ;

Overton, Edgar T. O. E. T. ;

Girard, Pierre-Marie G. P. M. ;

Oka, Shinichi O. S. ;

Walmsley, Sharon W. S. ;

Bettacchi, Chris B. C. ;

Brinson, Cynthia B. C. ;

Philibert, Patrick P. P. ;

Lombaard, Johan L. J. ;

Clair, Marty C. M. ;

Crauwels, Herta C. H. ;

Ford, Susan L. F. S. L. ;

Patel, Parul P. P. ;

Chounta, Vasiliki C. V. ;

D'Amico, Ronald D. R. ;

Vanveggel, Simon V. S. ;

Dorey, David D. D. ;

Cutrell, Amy C. A. ;

Griffith, Sandy G. S. ;

Margolis, David A. M. D. A. ;

Williams, Peter E. W. P. E. ;

Parys, Wim P. W. ;

Smith, Kimberly Y. S. K. Y. ;

Spreen, William R. S. W. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (12) :1124-1135

[8]

Rubenstein E, 2023, C RETR OPP INF SEATT

[9] 2019 update of the European AIDS Clinical Society Guidelines for treatment of people living with HIV version 10.0 [J].

Ryom, L. ;

Cotter, A. ;

De Miguel, R. ;

Beguelin, C. ;

Podlekareva, D. ;

Arribas, J. R. ;

Marzolini, C. ;

Mallon, P. G. M. ;

Rauch, A. ;

Kirk, O. ;

Molina, J. M. ;

Guaraldi, G. ;

Winston, A. ;

Bhagani, S. ;

Cinque, P. ;

Kowalska, J. D. ;

Collins, S. ;

Battegay, M. .

HIV MEDICINE, 2020, 21 (10) :617-624

[10] Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression [J].

Swindells, Susan ;

Andrade-Villanueva, Jaime-Federico ;

Richmond, Gary J. ;

Rizzardini, Giuliano ;

Baumgarten, Axel ;

Masia, Mar ;

Latiff, Gulam ;

Pokrovsky, Vadim ;

Bredeek, Fritz ;

Smith, Graham ;

Cahn, Pedro ;

Kim, Yeon-Sook ;

Ford, Susan L. ;

Talarico, Christine L. ;

Patel, Parul ;

Chounta, Vasiliki ;

Crauwels, Herta ;

Parys, Wim ;

Vanveggel, Simon ;

Mrus, Joseph ;

Huang, Jenny ;

Harrington, Conn M. ;

Hudson, Krischan J. ;

Margolis, David A. ;

Smith, Kimberly Y. ;

Williams, Peter E. ;

Spreen, William R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (12) :1112-1123

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