The wound healing effect of collagen/adipose-derived stem cells (ADSCs) hydrogel: In vivo study

被引:11
|
作者
Abbasi, Kamyar [1 ]
Tavakolizadeh, Sara [1 ]
Hadi, Alireza [1 ]
Hosseini, Maryam [2 ]
Soufdoost, Reza Sayyad [3 ]
Heboyan, Artak [4 ]
Alam, Mostafa [5 ]
Fani-Hanifeh, Sadaf [6 ]
机构
[1] Shahid Beheshti Univ Med Sci, Sch Dent, Dept Prosthodont, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Res Inst Dent Sci, Dent Res Ctr, Sch Dent, Tehran, Iran
[3] Shahed Univ, Dent Res Inst, Sch Dent, Tehran, Iran
[4] Yerevan State Med Univ Mkhitar Heratsi, Fac Stomatol, Dept Prosthodont, Yerevan, Armenia
[5] Shahid Beheshti Univ Med Sci, Sch Dent, Dept Oral & Maxillofacial Surg, Tehran, Iran
[6] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran
关键词
ADSCs; collagen; hydrogel; placenta; Wound healing; ADIPOSE-TISSUE; BONE REGENERATION; SKIN; SCAFFOLDS; VITRO; FABRICATION; MANAGEMENT; IBUPROFEN;
D O I
10.1002/vms3.1059
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
BackgroundThe complex wound healing process involves activating and synchronizing intracellular, intercellular, and extracellular components. Adipose tissue is attracting attention to promote wound healing. Within subcutaneous adipose tissue, stromal vascular cells and their subsets release growth factors and cytokines critical for neovascularization and wound repair. ObjectivesThis study evaluated human placental collagen/adipose-derived stem cells (ADSCs) hydrogel for wound healing in rats. MethodsIn this study, ADSCs were harvested, cultured, and mixed with placental collagen. Twelve rats were used, and their backs were excised three times each. Group one received collagen/ADSCs, group two collagen, and group three non-filled (control) excisions. The healing processes were assessed by histological analysis, taking photographs, and calculating the percentage of wound contraction in mentioned times. ResultsHistopathological analysis revealed that the content of fibroblasts, follicles of the hair, and angiogenesis in group one was significantly more than in other groups. Group one had a significant result compared with the collagen and control groups. In group one, significant wound healing and wound contraction were observed with 52% and 80% wound contraction at 7 and 14 days, respectively. ConclusionCollagen/ADSCs can be considered a suitable candidate hydrogel in wound healing with a high potential for enhancing wound repairing.
引用
收藏
页码:282 / 289
页数:8
相关论文
共 50 条
  • [1] Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing
    Mazini, Loubna
    Rochette, Luc
    Admou, Brahim
    Amal, Said
    Malka, Gabriel
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (04)
  • [2] Adipose-derived stem cells for wound healing
    Hassanshahi, Alireza
    Hassanshahi, Mohammadhossein
    Khabbazi, Samira
    Hosseini-Khah, Zahra
    Peymanfar, Yaser
    Ghalamkari, Saman
    Su, Yu-Wen
    Xian, Cory J.
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (06) : 7903 - 7914
  • [3] ADHESIVE INJECTABLE HYDROGEL ENCAPSULATED WITH ADIPOSE-DERIVED STEM CELLS FOR WOUND HEALING
    Lee, X. Y.
    Wang, W.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2015, 184 : 551 - 552
  • [4] Adipose-Derived Stem Cells for Wound Healing Applications
    Cherubino, Mario
    Rubin, J. Peter
    Miljkovic, Natasa
    Kelmendi-Doko, Arta
    Marra, Kacey G.
    ANNALS OF PLASTIC SURGERY, 2011, 66 (02) : 210 - 215
  • [5] Role of adipose-derived stem cells in wound healing
    Ul Hassan, Waqar
    Greiser, Udo
    Wang, Wenxin
    WOUND REPAIR AND REGENERATION, 2014, 22 (03) : 313 - 325
  • [6] The effect of human adipose-derived stem cells on the cutaneous wound healing
    Lee, S.
    Cho, K.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 : S41 - S41
  • [7] Comparable effect of adipose-derived stromal vascular fraction and mesenchymal stem cells for wound healing: An in vivo study
    Karina, Karina
    Rosadi, Imam
    Sobariah, Siti
    Afini, Irsyah
    Widyastuti, Tias
    Rosliana, Iis
    BIOMEDICAL RESEARCH AND THERAPY, 2019, 6 (10): : 3412 - 3421
  • [8] A biomimetic collagen-pullulan hydrogel enhances stemness and wound healing potential of adipose-derived mesenchymal stem cells
    Garg, Ravi K.
    Auerbach, Lauren J.
    Sorkin, Michael
    Rennert, Robert C.
    Longaker, Michael T.
    Gurtner, Geoffrey C.
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2012, 215 (03) : S96 - S96
  • [9] The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application
    Kim, Hyeonwoo
    Hyun, Mi Ri
    Kim, Sang Wha
    STEM CELLS INTERNATIONAL, 2019, 2019
  • [10] SKIN SUBSTITUTE WITH ADIPOSE-DERIVED STEM CELLS FOR WOUND HEALING, FROM AN INJECTABLE HYDROGEL SYSTEM
    Dong, Y.
    Khong, S.
    Rodrigues, M.
    Li, A. Y.
    Zhou, D.
    Gao, Y.
    Brett, E. A.
    Wang, W.
    Gurtner, G. C.
    WOUND REPAIR AND REGENERATION, 2016, 24 (02) : A7 - A7