Choroid plexus volume in multiple sclerosis can be estimated on structural MRI avoiding contrast injection

被引：5

作者：

Visani, Valentina ^{[1
]}

Pizzini, Francesca B. ^{[2
]}

Natale, Valerio ^{[3
]}

Tamanti, Agnese ^{[4
]}

Anglani, Mariagiulia ^{[5
]}

Bertoldo, Alessandra ^{[1
,6
]}

Calabrese, Massimiliano ^{[4
]}

Castellaro, Marco ^{[1
]}

机构：

[1] Univ Padua, Dept Informat Engn, Padua, Italy

[2] Univ Verona, Dept Engn Innovat Med, Verona, Italy

[3] Univ Verona, Dept Diagnost & Publ Hlth, Verona, Italy

[4] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[5] Univ Hosp Padova, Neuroradiol Unit, Padua, Italy

[6] Univ Padua, Padova Neurosci Ctr, Padua, Italy

来源：

EUROPEAN RADIOLOGY EXPERIMENTAL | 2024年 / 8卷 / 01期

关键词：

Choroid plexus; Gadolinium-based contrast media; Image segmentation; Magnetic resonance imaging; Multiple sclerosis; SEGMENTATION; ENLARGEMENT; INVOLVEMENT; ALZHEIMERS; RELEVANCE;

D O I：

10.1186/s41747-024-00421-9

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We compared choroid plexus (ChP) manual segmentation on non-contrast-enhanced (non-CE) sequences and reference standard CE T1- weighted (T1w) sequences in 61 multiple sclerosis patients prospectively included. ChP was separately segmented on T1w, T2-weighted (T2w) fluid-attenuated inversion-recovery (FLAIR), and CE-T1w sequences. Inter-rater variability assessed on 10 subjects showed high reproducibility between sequences measured by intraclass correlation coefficient (T1w 0.93, FLAIR 0.93, CE-T1w 0.99). CE-T1w showed higher signal-to-noise ratio and contrast-to-noise ratio (CE-T1w 23.77 and 18.49, T1w 13.73 and 7.44, FLAIR 13.09 and 10.77, respectively). Manual segmentation of ChP resulted 3.073 +/- 0.563 mL (mean +/- standard deviation) on T1w, 3.787 +/- 0.679 mL on FLAIR, and 2.984 +/- 0.506 mL on CE-T1w images, with an error of 28.02 +/- 19.02% for FLAIR and 3.52 +/- 12.61% for T1w. FLAIR overestimated ChP volume compared to CE-T1w (p < 0.001). The Dice similarity coefficient of CE-T1w versus T1w and FLAIR was 0.67 +/- 0.05 and 0.68 +/- 0.05, respectively. Spatial error distribution per slice was calculated after nonlinear coregistration to the standard MNI152 space and showed a heterogeneous profile along the ChP especially near the fornix and the hippocampus. Quantitative analyses suggest T1w as a surrogate of CE-T1w to estimate ChP volume.

引用

页数：10

共 31 条

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