Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review

被引:2
|
作者
Wang, Qianxinhong [1 ]
Su, Wenlong [2 ]
Liu, Junnan [3 ]
Zhao, Dongkai [3 ]
机构
[1] Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun, Peoples R China
[2] Changchun Univ Chinese Med, Coll Pharm, Changchun, Peoples R China
[3] Changchun Univ Tradit Chinese Med, Clin Hosp 3, Changchun 130117, Peoples R China
关键词
autophagy; COPD; etiology; EPITHELIAL-CELL APOPTOSIS; OXIDATIVE STRESS; SELECTIVE AUTOPHAGY; LUNG-DISEASE; COPD; INFLAMMATION; MECHANISMS; EMPHYSEMA; DEATH; CILIA;
D O I
10.1097/MD.0000000000036390
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness. It arises from emphysema and chronic bronchitis and is characterized by progressive and irreversible airflow limitation and chronic inflammation of the lungs, which eventually progresses to pulmonary hypertension, chronic pulmonary heart disease and respiratory failure. Autophagy is a highly conserved cellular homeostasis maintenance mechanism that involves the transport of damaged organelles and proteins to lysosomes for destruction. Dysregulation of autophagy is one of the pathogenic mechanisms of many diseases and is strongly associated with the development of COPD, although the precise mechanisms are unknown. In this paper, we focus on macroautophagy, a type of autophagy that has been thoroughly studied, and describe the characteristics, processes, regulatory pathways, and functions of autophagy, and discuss its relationship with COPD from the perspectives of inflammation, emphysema, mucus hypersecretion, cilia structure and function, airway remodeling, vascular remodeling, and bacterial infections, with a view to searching for the therapeutic targets of COPD from the perspective of autophagy, which is hoped to be helpful for the clinical treatment.
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页数:7
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