Efficacy and safety of vonoprazan-based regimen for Helicobacter pylori eradication therapy in Japanese adolescents: a prospective multicenter study

被引：13

作者：

Kakiuchi, Toshihiko ^{[1
]}

Matsuo, Muneaki ^{[1
]}

Endo, Hiroyoshi ^{[2
]}

Sakata, Yasuhisa ^{[3
]}

Esaki, Motohiro ^{[3
]}

Noda, Takahiro ^{[4
]}

Imamura, Ichiro ^{[5
]}

Hashiguchi, Kazutoshi ^{[5
]}

Ogata, Shinichi ^{[6
]}

Fujioka, Yasuhiko ^{[7
]}

Hanada, Keiichiro ^{[8
]}

Fukuda, Kayoko ^{[9
]}

Yoshimura, Masaya ^{[10
]}

Kajiwara, Tetsuro ^{[11
]}

Yamamoto, Kentaroh ^{[12
]}

Yamaguchi, Daisuke ^{[13
]}

Kawakubo, Hiroharu ^{[14
]}

Matsunaga, Takuya ^{[15
]}

Sumino, Michihiro ^{[16
]}

Matsunaga, Keiji ^{[17
]}

Muro, Eriko ^{[18
]}

Watanabe, Akira ^{[19
]}

Fujimoto, Kazuma ^{[20
]}

机构：

[1] Saga Univ, Fac Med, Dept Pediat, Saga, Japan

[2] Saiseikai Karatsu Hosp, Dept Internal Med, Karatsu, Japan

[3] Saga Univ, Fac Med, Dept Internal Med, Div Gastroenterol, Saga, Japan

[4] Karatsu Red Cross Hosp, Dept Internal Med, Karatsu, Japan

[5] Imamura Hosp, Dept Gastroenterol, Tosu, Japan

[6] Saga Ken Med Ctr Koseikan, Dept Gastroenterol, Saga, Japan

[7] Fujioka Hosp, Dept Gastroenterol, Saga, Japan

[8] Hashimoto Hosp, Dept Surg, Kanzaki, Japan

[9] Hiramatsu Hosp, Dept Gastroenterol, Ogi, Japan

[10] Natl Hosp Org East Saga Hosp, Dept Gastroenterol, Miyaki, Japan

[11] Shiroishikyoritsu Hosp, Dept Gastroenterol, Shiroishi, Japan

[12] Yamamoto Mem Hosp, Dept Surg, Imari, Japan

[13] Natl Hosp Org Ureshino Med Ctr, Dept Gastroenterol, Ureshino, Japan

[14] Imari Arita Kyouritsu Hosp, Dept Gastroenterol, Arita, Japan

[15] Natl Hosp Org Saga Hosp, Dept Internal Med, Saga, Japan

[16] Inutsuka Hosp, Dept Internal Med, Kashima, Japan

[17] Oda Hosp, Dept Gastroenterol, Kashima, Japan

[18] Takashima Hosp, Dept Pediat, Shiroishi, Japan

[19] Taku City Hosp, Dept Internal Med, Taku, Japan

[20] Int Univ Hlth & Welf, Dept Gastroenterol, Okawa, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2023年 / 58卷 / 03期

关键词：

Helicobacter pylori; Abdominal pain; Urticaria; COMPETITIVE ACID BLOCKER; NEGATIVE GASTRIC-CANCER; TRIPLE THERAPY; ANTIMICROBIAL RESISTANCE; ENDOSCOPIC RESECTION; ANTIBODY-TEST; OPEN-LABEL; CHILDREN; INFECTION; 1ST-LINE;

D O I：

10.1007/s00535-022-01942-z

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Vonoprazan (VPZ)-based regimen for Helicobacter pylori (H. pylori) is safe and more efficacious than the proton pump inhibitor-based regimen mainly in adults. This study aimed to evaluate the efficacy and safety of a VPZ-based regimen for H. pylori eradication therapy in adolescents. Methods An H. pylori screening and treatment longitudinal project for third-year junior high school students in Saga Prefecture began in 2016. Students who tested positive for both urine and stool tests received a VPZ-based regimen. On the checklist, students were asked for diarrhea, fever, abdominal pain, nausea, vomiting, urticaria, dysgeusia, or bloody stool occurrence during the therapy. Results The longitudinal project for H. pylori screening and treatment among third-grade students in Saga Prefecture targeted 41,115 students from 2017 to 2021 and 836 as positive. Of the 645 students, 542 (84.0% in per protocol [PP] analysis and 73.6% in intention-to-treat [ITT] analysis) were successful in primary eradication therapy. The secondary eradication therapy was successful in 79 (96.3% in PP analysis and 76.7% in ITT analysis) of 82 students. In the primary eradication therapy, abdominal pain occurred in 164 (27.9%), diarrhea in 217 (36.9%), nausea or vomiting in 7 (1.2%), and urticaria in 13 (2.2%) students. In the secondary eradication therapy, abdominal pain occurred in 12 (19.4%) and diarrhea in 17 (27.4%) students. The eradication therapy of 5 students was interrupted due to adverse events only by primary eradication therapy. Conclusions VPZ-based regimen for H. pylori was efficacious and safe for adolescents, as in adults, for both primary and secondary eradication therapies.

引用

页码：196 / 204

页数：9

共 45 条

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