Cu-catalyzed three-component aminodifluoroalkylative cyclization of styrenes: Access to α,α-difluoro-γ-lactams

被引：0
作者：
Zhu, Fengxiang [1 ]
Luo, Jiajia [1 ]
Zhang, Pengbo [2 ]
机构：
[1] Shanxi Univ, Sch Chem & Chem Engn, Wucheng Rd 92, Taiyuan 030006, Peoples R China
[2] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China
来源：
MOLECULAR CATALYSIS | 2024年 / 556卷
基金：
中国国家自然科学基金;
关键词：
Copper; Aminodifluoroalkylation; Cyclization; Styrenes; Three-component; GAMMA-LACTAMS; BIOLOGICAL EVALUATION; FLUORINATION; TRIFLUOROMETHYLATION; CARBOAMINATION; INHIBITORS; EFFICIENT;
D O I：
10.1016/j.mcat.2024.113899
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We describe a simple, practical copper-catalyzed intermolecular three-component aminodifluoroalkylative cyclization reaction of alkenes with ethyl bromodifluoroacetate and anilines to alpha,alpha-difluoro-gamma-lactams in one step. Contrary to related carboamination reactions, in addition to electron-rich vinylarenes, electron-neutral and electron-poor styrenes can also be functionalized. Preliminary mechanistic studies demonstrate the involvement of carbon-centered radical, while ruling out the possibility of bromodifluoroacetamide intermediate.
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页数：5
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