Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms

被引：31

作者：

de Almeida, Viviani ^{[1
]}

Engel, Daiane F. ^{[2
]}

Ricci, Mayra F. ^{[1
]}

Cruz, Clenio Silva ^{[1
]}

Lopes, Icaro Santos ^{[3
]}

Alves, Daniele Almeida ^{[4
]}

D' Auriol, Mirna ^{[5
]}

Magalhaes, Joao ^{[1
]}

Machado, Elayne C. ^{[1
]}

Rocha, Victor M. ^{[1
]}

Carvalho, Toniana G. ^{[6
]}

Lacerda, Larisse S. B. ^{[7
]}

Pimenta, Jordane C. ^{[7
]}

Aganetti, Mariana ^{[1
]}

Zuccoli, Giuliana S. ^{[8
]}

Smith, Bradley J. ^{[8
]}

Carregari, Victor C. ^{[8
]}

Rosa, Erika da Silva ^{[1
]}

Galvao, Izabela ^{[1
]}

Cassali, Geovanni Dantas ^{[9
]}

Garcia, Cristiana C. ^{[10
]}

Teixeira, Mauro Martins ^{[7
]}

Andre, Leiliane C. ^{[5
]}

Ribeiro, Fabiola Mara ^{[6
]}

Martins, Flaviano S. ^{[11
]}

Saia, Rafael Simone ^{[12
]}

Costa, Vivian Vasconcelos ^{[7
]}

Martins-de-Souza, Daniel ^{[8
,13
,14
,15
]}

Hansbro, Philip M. ^{[16
,17
]}

Marques, Joao Trindade ^{[4
,18
]}

Aguiar, Eric R. G. R. ^{[3
]}

Vieira, Angelica T. ^{[1
,19
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Inst Biol Sci, Dept Biochem & Immunol, Lab Microbiota & Immunomodulat, Belo Horizonte, Brazil

[2] Univ Fed Ouro Preto UFOP, Sch Pharm, Dept Clin Anal, Ouro Preto, Brazil

[3] Univ Estadual Santa Cruz UESC, Ctr Biotechnol & Genet, Dept Biol Sci, Lab Virus Bioinformat, Ilheus, Brazil

[4] Univ Fed Minas Gerais UFMG, Inst Biol Sci, Dept Biochem & Immunol, Lab RNA Interference & Antiviral Immun, Belo Horizonte, Brazil

[5] Univ Fed Minas Gerais UFMG, Fac Pharm, Dept Clin & Toxicol Anal, Lab Toxicol, Belo Horizonte, Brazil

[6] Univ Fed Minas Gerais UFMG, Inst Biol Sci, Dept Biochem & Immunol, Lab Neurobiochem, Belo Horizonte, Brazil

[7] Univ Fed Minas Gerais UFMG, Inst Biol Sci, Ctr Res & Dev Drugs, Dept Morphol, Belo Horizonte, Brazil

[8] Univ Estado Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroproteom, Campinas, Brazil

[9] Univ Fed Minas Gerais UFMG, Dept Pathol, Lab Comparat Pathol, Belo Horizonte, Brazil

[10] Inst Oswaldo Cruz Fiocruz, Lab Resp Viruses & Measles, Rio de Janeiro, Brazil

[11] Univ Fed Minas Gerais UFMG, Inst Biol Sci, Dept Microbiol, Lab Biotherapeut Agents, Belo Horizonte, Brazil

[12] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Lab Intestinal Physiol, Ribeirao Preto, Brazil

[13] DOR Inst Res & Educ, Sao Paulo, Brazil

[14] Univ Estado Campinas UNICAMP, Expt Med Res Cluster, Campinas, Brazil

[15] Natl Inst Biomarkers Neuropsychiat, Natl Council Sci & Technol Dev, Sao Paulo, Brazil

[16] Univ Technol Sydney, Centenary Inst, Ctr Inflammat, Sydney, Australia

[17] Univ Technol Sydney, Sydney, Australia

[18] Univ Strasbourg, CNRS UPR9022, Strasbourg, France

[19] Univ Fed Minas Gerais UFMG, Inst Biol Sci, Lab Microbiota & Immunomodulat, Av Pres Antonio Carlos,6627, Belo Horizonte, Brazil

来源：

GUT MICROBES | 2023年 / 15卷 / 02期

关键词：

COVID-19; SARS-CoV-2; post-COVID; microbiota; inflammation; antimicrobial-resistance; SARS-COV-2; RNA; INFECTION; MODEL; DISEASE; HUMANS;

D O I：

10.1080/19490976.2023.2249146

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Long-term sequelae of coronavirus disease (COVID)-19 are frequent and of major concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to disease severity in patients with COVID-19. Here, we report that the gut microbiota of post-COVID subjects had a remarkable predominance of Enterobacteriaceae strains with an antibiotic-resistant phenotype compared to healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced in feces. Fecal transplantation from post-COVID subjects to germ-free mice led to lung inflammation and worse outcomes during pulmonary infection by multidrug-resistant Klebsiella pneumoniae. transplanted mice also exhibited poor cognitive performance. Overall, we show prolonged impacts of SARS-CoV-2 infection on the gut microbiota that persist after subjects have cleared the virus. Together, these data demonstrate that the gut microbiota can directly contribute to post-COVID sequelae, suggesting that it may be a potential therapeutic target.

引用

页数：22

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