Supramolecular assembly of benzocaine bearing cyclodextrin cavity via host-guest complexes on polyacrylonitrile as an electrospun nanofiber

Nanofibers (NFs) can be encapsulated with cyclodextrins (CDs) based host-guest complexes (HCs) in order to enable many biological applications. Here, benzocaine (BNZ) forms HCs with 8-cyclodextrin (8-CD) that are coprecipitated and further added to polyacrylonitrile (PAN) solution for making BNZ:8-CD-HCs/PAN NFs material with the aid of electrospinning technique. The marginal increase in absorbance and fluorescence intensity along with the shift in spectral maxima of BNZ in the presence of 8-CD suggested the host-guest interaction between BNZ and 8-CD. NFs showed a uniform and clean morphology in SEM images and interestingly, the ICs revealed that significantly thinner in terms of average fiber diameter (AFD) than those of free BNZ on PAN medium. BNZ molecule is completely included in the PAN surface as the result of NFs and thus, the original sharp peaks for the BNZ have vanished and the peaks are much broader for the BNZ and BNZ:8-CD-HCs. BNZ is also found to be a good candidate for anti-inflammatory, anti-oxidant, and anti-diabetic. The results showed an improved activity when it is in the form of HCs on a PAN medium. Making HCs of drugs could be significant in biological applications.