Relationship between Platelet Index and Lipid Metabolism, Coagulation Function, and Inflammation in Diabetic Patients

被引：1

作者：

Liu, Wen ^{[1
,2
,3
]}

Zhu, Jing ^{[1
,2
,3
]}

Cheng, JiBing ^{[1
,2
,3
]}

Tang, Qian ^{[1
,2
,3
]}

Long, Siqi ^{[1
,2
,3
]}

机构：

[1] North Sichuan Med Coll, Dept Clin Lab, Affiliated Hosp, 63 Wenhua Rd, Nanchong 637002, Sichuan, Peoples R China

[2] North Sichuan Med Coll, Dept Lab Med, Nanchong, Sichuan, Peoples R China

[3] North Sichuan Med Coll, Translat Med Res Ctr, Nanchong, Sichuan, Peoples R China

来源：

CLINICAL LABORATORY | 2024年 / 70卷 / 01期

关键词：

mean platelet volume; platelet distribution width; lipid metabolism; coagulation function; inflammation; VON-WILLEBRAND-FACTOR; VASCULAR-DISEASE; TYPE-2; PATHOPHYSIOLOGY; MELLITUS; VOLUME; ASSOCIATION; ACTIVATION; GLUCOSE; MARKERS;

D O I：

10.7754/Clin.Lab.2023.230635

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Platelets are overactive in type 2 diabetes mellitus (T2DM). This study analyzed the relationship between platelet index and lipid metabolism, coagulation function, and inflammation in T2DM patients. Methods: This study enrolled 60 T2DM patients and 60 healthy subjects (age- and gender-matched). Mean platelet volume (MPV) and platelet distribution width (PDW) were evaluated, and their associations with lipid metabolism (TG and HDL-C), coagulation function (vWF and PAI-1), and inflammation (IL-6 and TNF-alpha) were analyzed. Results: T2DM patients had increased MPV and PDW. Furthermore, the platelet index was correlated with the levels of TG, HDL-C, vWF, PAI-1, IL-6, and TNF-alpha. Conclusions: MPV and PDW are increased in T2DM patients. Moreover, platelet index was associated with lipid metabolism disorder, coagulation dysfunction, and inflammatory response in T2DM patients.

引用

页码：119 / 124

页数：6

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