Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers

被引:2
|
作者
Cordoba-Lanus, Elizabeth [1 ,2 ,3 ]
Montuenga, Luis M. [4 ,5 ,6 ,7 ]
Dominguez-de-Barros, Angelica [2 ]
Oliva, Alexis [2 ,8 ]
Mayato, Delia [9 ]
Remirez-Sanz, Ana [5 ]
Gonzalvo, Francisca [9 ]
Celli, Bartolome [10 ]
Zulueta, Javier J. [11 ]
Casanova, Ciro [1 ,9 ,12 ]
机构
[1] Univ La Laguna, Dept Internal Med Dermatol & Psychiat, San Cristobal De La Lagun 38296, Spain
[2] Inst Enfermedades Trop & Salud Publ Canarias IUETS, San Cristobal De La Lagun 38029, Spain
[3] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas CIB, Madrid 28029, Spain
[4] Univ Navarra, Sch Med & Sci, Dept Pathol Anat & Physiol, Pamplona 31008, Spain
[5] Univ Navarra, CIMA Ctr Invest Med Aplicada, Pamplona 31008, Spain
[6] Navarra Inst Hlth Res IdISNA, Pamplona 31008, Spain
[7] Ctr Invest Biomed Red Canc CIBERONC, Madrid 28029, Spain
[8] Univ Laguna, Dept Pharmaceut Technol, San Cristobal De La Lagun 38296, Spain
[9] Hosp Univ Nuestra Senora Candelaria, Pulm Div, Res Unit, Santa Cruz De Tenerife 38010, Spain
[10] Harvard Med Sch, Brigham & Womens Hosp, Pulm Crit Care Med Div, Boston, MA 02115 USA
[11] Mt Sinai Morningside Hosp, Icahn Sch Med, Pulm Crit Care & Sleep Med Div, New York, NY 10025 USA
[12] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Respiratorias C, Madrid 28029, Spain
关键词
lung cancer; COPD; telomeres; oxidative stress; 8-OHdG; biomarkers; DNA-DAMAGE; RISK; ASSOCIATION; 8-OHDG; PATHOGENESIS;
D O I
10.3390/antiox13020156
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallmark of aging, and 8-OHdG concentrations, indicative of oxidative DNA damage, as risk biomarkers of LC was evaluated in COPD patients three years prior to LC diagnosis. Relative telomere length measured using qPCR and serum levels of 8-OHdG were determined at the baseline in 99 COPD smokers (33 with LC and 66 age-matched COPD without LC as controls). Of these, 21 COPD with LC and 42 controls had the biomarkers measured 3 years before. Single nucleotide variants (SNVs) in TERT, RTEL, and NAF1 genes were also determined. COPD cases were evaluated, which showed greater telomere length (p < 0.001) and increased serum 8-OHdG levels (p = 0.004) three years prior to LC diagnosis compared to the controls. This relationship was confirmed at the time of LC diagnosis. No significant association was found between the studied SNVs in cases vs. controls. In conclusion, this preliminary study shows that longer leucocyte telomere length and increased 8-OHdG serum levels can be useful as early biomarkers of the risk for future lung cancer development among COPD patients.
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页数:13
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