Incidence of muscle symptoms in placebo arm among statin-intolerant patients: a systematic review with meta-analysis

被引:0
作者
Louro, Rita [1 ]
Melo, Ryan [1 ,2 ,3 ]
Ruivo, Jorge [1 ,3 ]
Almeida, Ana [1 ,3 ,4 ]
Pinto, Fausto [1 ,3 ,4 ]
Caldeira, Daniel [1 ,3 ,4 ,5 ,6 ]
机构
[1] Univ Lisbon, Fac Med, Lisbon, Portugal
[2] Ctr Hosp Univ Lisboa Norte, Hosp Santa Maria, Vasc Surg Heart & Vessels Dept, Lisbon, Portugal
[3] Univ Lisbon, Cardiovasc Univ Lisboa CCUL CCUL RISE, Fac Med, Lisbon, Portugal
[4] Hosp Univ Santa Maria CHLN, Ctr Acad Med Lisboa CAML, Cardiol Dept, Lisbon, Portugal
[5] Univ Lisbon, Fac Med, Lab Clin Pharmacol & Therapeut, Lisbon, Portugal
[6] Univ Lisbon, Cardiovasc Univ Lisboa CCUL CCUL RISE, Fac Med, Ae Prof Egas Moniz,Av Prof Lisboa, P-1649028 Lisbon, Portugal
关键词
Statin; placebo; muscle symptoms; systematic review; SAMS; drucebo; nocebo; RISK; PREVALENCE; EFFICACY; TRIAL; CHOLESTEROL; STATEMENT; SAFETY; BIAS;
D O I
10.1080/14779072.2023.2274502
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
IntroductionStatins are highly used in cardiovascular prevention. Statin intolerance is the most significant cause of decreased adherence, translating into a higher cardiovascular risk. This systematic review aims to estimate the incidence of muscle adverse events in patients with a history of statin intolerance receiving placebo.MethodsDatabase search was performed in CENTRAL, MEDLINE, and EMBASE until March 2023. This systematic review included blinded randomized control trials enrolling patients with a history of statin intolerance who received a placebo. A random-effects meta-analysis was performed. Results were presented in percentages, with 95% confidence intervals (95% CI).ResultsOverall, eight studies with 8095 patients with a history of statin intolerance receiving placebo were included. The muscle adverse events incidence rate was 21.34% (95% CI 13.26-30.63%, 8 studies), and discontinuation due to adverse muscle events was 6.12% (95% CI 1.22-13.70%, 3 studies). The incidence was higher in subcutaneous placebo/sham (41.67%, 1 study) compared to oral placebo studies (22.95%, 6 studies).ConclusionIn patients previously labeled as statin-intolerant, about a fifth of the patients exhibited muscle symptoms when receiving a placebo. This highlights the importance of ruling out non-statin-related symptoms to further optimize statin therapy for cardiovascular risk improvement.
引用
收藏
页码:887 / 894
页数:8
相关论文
共 35 条
[1]   Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials [J].
Baigent, C. ;
Blackwell, L. ;
Emberson, J. ;
Holland, L. E. ;
Reith, C. ;
Bhala, N. ;
Peto, R. ;
Barnes, E. H. ;
Keech, A. ;
Simes, J. ;
Collins, R. .
LANCET, 2010, 376 (9753) :1670-1681
[2]   Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel [J].
Banach, Maciej ;
Rizzo, Manfredi ;
Toth, Peter P. ;
Farnier, Michel ;
Davidson, Michael H. ;
Al-Rasadi, Khalid ;
Aronow, Wilbert S. ;
Athyros, Vasilis ;
Djuric, Dragan M. ;
Ezhov, Marat V. ;
Greenfield, Robert S. ;
Hovingh, G. Kees ;
Kostner, Karam ;
Serban, Corina ;
Lighezan, Daniel ;
Fras, Zlatko ;
Moriarty, Patrick M. ;
Muntner, Paul ;
Goudev, Assen ;
Ceska, Richard ;
Nicholls, Stephen J. ;
Broncel, Marlena ;
Nikolic, Dragana ;
Pella, Daniel ;
Puri, Raman ;
Rysz, Jacek ;
Wong, Nathan D. ;
Bajnok, Laszlo ;
Jones, Steven R. ;
Ray, Kausik K. ;
Mikhailidis, Dimitri P. .
ARCHIVES OF MEDICAL SCIENCE, 2015, 11 (01) :1-23
[3]   Meta-analysis of prevalence [J].
Barendregt, Jan J. ;
Doi, Suhail A. ;
Lee, Yong Yi ;
Norman, Rosana E. ;
Vos, Theo .
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 2013, 67 (11) :974-978
[4]  
Bytyci I., 2022, EUR HEART J, V19, P1
[5]   NLA scientific statement on statin intolerance: a new definition and key considerations for ASCVD risk reduction in the statin intolerant patient [J].
Cheeley, Mary Katherine ;
Saseen, Joseph J. ;
Agarwala, Anandita ;
Ravilla, Sudha ;
Ciffone, Nicole ;
Jacobson, Terry A. ;
Dixon, Dave L. ;
Maki, Kevin C. .
JOURNAL OF CLINICAL LIPIDOLOGY, 2022, 16 (04) :361-375
[6]   Statins for Prevention of Cardiovascular Disease in Adults Evidence Report and Systematic Review for the US Preventive Services Task Force [J].
Chou, Roger ;
Dana, Tracy ;
Blazina, Ian ;
Daeges, Monica ;
Jeanne, Thomas L. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 316 (19) :2008-2024
[7]   METAANALYSIS IN CLINICAL-TRIALS [J].
DERSIMONIAN, R ;
LAIRD, N .
CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188
[8]   The importance of placebo in headache research [J].
Diener, H-C ;
Schorn, C. F. ;
Bingel, U. ;
Dodick, D. W. .
CEPHALALGIA, 2008, 28 (10) :1003-1011
[9]   Bias in meta-analysis detected by a simple, graphical test [J].
Egger, M ;
Smith, GD ;
Schneider, M ;
Minder, C .
BMJ-BRITISH MEDICAL JOURNAL, 1997, 315 (7109) :629-634
[10]  
Emberson JR, 2012, PLOS ONE, V7, DOI [10.1016/S0140-6736(12)60367-5, 10.1371/journal.pone.0029849]