Characteristics Predicting Short-Term and Long-Term Health-Related Quality of Life in Patients with Esophageal Cancer After Neoadjuvant Chemoradiotherapy and Esophagectomy

被引:6
作者
van der Wilk, Berend J. J. [1 ]
Eyck, Ben M. M. [1 ]
Noordman, Bo J. J. [1 ]
Kranenburg, Leonieke W. W. [2 ]
Oppe, Mark [3 ]
Lagarde, Sjoerd M. M. [1 ]
Wijnhoven, Bas P. L. [1 ]
Busschbach, Jan J. J. [2 ]
van Lanschot, J. Jan B. [1 ]
机构
[1] Erasmus MC Canc Inst, Univ Med Ctr, Dept Surg, Rotterdam, Netherlands
[2] Erasmus MC Univ Med Ctr, Dept Psychiat, Sect Med Psychol & Psychotherapy, Rotterdam, Netherlands
[3] Maths Hlth, Rotterdam, Netherlands
关键词
Esophageal cancer; Neoadjuvant chemoradiotherapy; Health-related quality of life; Active surveillance; ACTIVE SURVEILLANCE; CLINICAL-TRIALS; PLUS SURGERY; MANAGEMENT; RESECTION; QLQ-C30; ANXIETY;
D O I
10.1245/s10434-023-14028-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundEsophagectomy is associated with lasting effect on health-related quality of life (HRQOL). Patients desire detailed information on the expected impact of treatment on their postoperative HRQOL. The aim of the present study is to identify clinicopathological characteristics predictive for changes in short-term and long-term HRQOL after neoadjuvant chemoradiotherapy (nCRT) and surgery.MethodsHRQOL was measured using EORTC-QLQ-C30 and QLQ-OES24 questionnaires prior to nCRT, three, six, nine and twelve months postoperatively and at a minimum of six years postoperatively. Based on previous experience and available literature, several subgroups were predefined for different clinicopathological characteristics: baseline global HRQOL, WHO performance status, histology, tumor stage and tumor location. The primary endpoints of the present study were the change compared to baseline in the HRQOL dimensions physical functioning and eating problems. Secondary endpoints were global HRQOL, fatigue and emotional problems.ResultsIn total, 134 (76%) of 177 patients who received HRQOL questionnaires, responded at baseline. Patients who reported a high baseline global HRQOL had a more severe deterioration in eating problems (+14.5 to + 18.0), global HRQOL (-16.0 to -28.0) and fatigue (+10.5 to +14.9) up to six years postoperatively compared to patients who reported a low baseline global HRQOL. Patients who had stage 2 tumor (UICC 6th edition) had a more severe deterioration in eating problems (+14.6 to +19.0) and global HRQOL (-10.1 to -17.1) than patients who had stage 3 tumor.ConclusionsThe results suggest that patients with locally advanced esophageal cancer in favorable condition at baseline decline more in terms of various HRQOL outcomes.
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收藏
页码:8192 / 8202
页数:11
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