Crosstalk between m6A and coding/non-coding RNA in cancer and detection methods of m6A modification residues

被引:0
作者
Meng, Qingren [1 ]
Schatten, Heide [2 ]
Zhou, Qian [3 ]
Chen, Jun [1 ]
机构
[1] Southern Univ Sci & Technol, Second Hosp, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Guangdong, Peoples R China
[2] Univ Missouri, Dept Vet Pathobiol, Columbia, MO 65211 USA
[3] Shenzhen Univ, Med Sch, Int Canc Ctr, Shenzhen, Guangdong, Peoples R China
来源
AGING-US | 2023年 / 15卷 / 13期
关键词
METTL3-MEDIATED M(6)A MODIFICATION; METHYLTRANSFERASE METTL3 PROMOTES; SINGLE-NUCLEOTIDE-RESOLUTION; STEM-LIKE CELLS; MESSENGER-RNA; HEPATOCELLULAR-CARCINOMA; N6-METHYLADENOSINE SITES; M6A-DEPENDENT MANNER; COLORECTAL-CANCER; BREAST-CANCER;
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
N6-methyladenosine (m6A) is one of the most common and well-known internal RNA modifications that occur on mRNAs or ncRNAs. It affects various aspects of RNA metabolism, including splicing, stability, translocation, and translation. An abundance of evidence demonstrates that m6A plays a crucial role in various pathological and biological processes, especially in tumorigenesis and tumor progression. In this article, we introduce the potential functions of m6A regulators, including "writers" that install m6A marks, "erasers" that demethylate m6A, and "readers" that determine the fate of m6A-modified targets. We have conducted a review on the molecular functions of m6A, focusing on both coding and noncoding RNAs. Additionally, we have compiled an overview of the effects noncoding RNAs have on m6A regulators and explored the dual roles of m6A in the development and advancement of cancer. Our review also includes a detailed summary of the most advanced databases for m6A, state-of-the-art experimental and sequencing detection methods, and machine learning-based computational predictors for identifying m6A sites.
引用
收藏
页码:6577 / 6619
页数:43
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