Propensity-Score Matched Analysis of the Effectiveness of Baricitinib in Patients With Coronavirus Disease 2019 (COVID-19) Using Nationwide Real-World Data: An Observational Matched Cohort Study From the Japan COVID-19 Task Force

被引：4

作者：

Tanaka, Hiromu ^{[1
]}

Chubachi, Shotaro ^{[1
]}

Namkoong, Ho ^{[2
]}

Sato, Yasunori ^{[3
]}

Asakura, Takanori ^{[1
]}

Lee, Ho ^{[1
]}

Azekawa, Shuhei ^{[1
]}

Otake, Shiro ^{[1
]}

Nakagawara, Kensuke ^{[1
]}

Fukushima, Takahiro ^{[1
]}

Watase, Mayuko ^{[1
]}

Sakurai, Kaori ^{[1
]}

Kusumoto, Tatsuya ^{[1
]}

Kondo, Yasushi ^{[4
]}

Masaki, Katsunori ^{[1
]}

Kamata, Hirofumi ^{[1
]}

Ishii, Makoto ^{[1
]}

Kaneko, Yuko ^{[4
]}

Hasegawa, Naoki ^{[2
]}

Ueda, Soichiro ^{[5
]}

Sasaki, Mamoru ^{[5
]}

Izumo, Takehiro ^{[6
]}

Inomata, Minoru ^{[6
]}

Miyazawa, Naoki ^{[7
]}

Kimura, Yasuhiro ^{[7
]}

Suzuki, Yusuke ^{[8
]}

Harada, Norihiro ^{[9
,10
]}

Ichikawa, Masako ^{[9
,10
]}

Takata, Tohru ^{[11
]}

Ishikura, Hiroyasu ^{[12
]}

Yoshiyama, Takashi ^{[13
]}

Kokuto, Hiroyuki ^{[13
]}

Murakami, Koji ^{[14
]}

Sano, Hirohito ^{[14
]}

Ueda, Tetsuya ^{[15
]}

Kuwahara, Naota ^{[16
]}

Fujiwara, Akiko ^{[16
]}

Ogura, Takashi ^{[17
]}

Inoue, Takashi ^{[18
]}

Asami, Takahiro ^{[18
]}

Mutoh, Yoshikazu ^{[19
]}

Nakachi, Ichiro ^{[20
]}

Baba, Rie ^{[19
]}

Nishi, Koichi ^{[21
]}

Tani, Mayuko ^{[21
]}

Kagyo, Junko ^{[22
]}

Hashiguchi, Mizuha ^{[22
]}

Oguma, Tsuyoshi ^{[23
]}

Asano, Koichiro ^{[23
]}

Nishikawa, Masanori ^{[24
]}

机构：

[1] Keio Univ, Dept Internal Med, Div Pulm Med, Sch Med, 35 Shinanomachi, Tokyo, Tokyo 1608582, Japan

[2] Keio Univ, Dept Infect Dis, Sch Med, 35 Shinanomachi, Tokyo, Tokyo 1608582, Japan

[3] Keio Univ, Dept Prevent Med & Publ Hlth, Sch Med, Tokyo, Japan

[4] Keio Univ, Dept Internal Med, Div Rheumatol, Sch Med, Tokyo, Japan

[5] JCHO Japan Community Hlth Care Org Saitama Med Ctr, Internal Med, Saitama, Japan

[6] Japanese Red Cross Med Ctr, Tokyo, Japan

[7] Saiseikai Yokohamashi Nanbu Hosp, Dept Resp Med, Yokohama, Japan

[8] Kitasato Univ, Dept Resp Med, Kitasato Inst Hosp, Tokyo, Japan

[9] Juntendo Univ, Fac Med, Dept Resp Med, Tokyo, Japan

[10] Grad Sch Med, Tokyo, Japan

[11] Fukuoka Univ Hosp, Dept Infect Control, Fukuoka, Japan

[12] Fukuoka Univ, Dept Emergency & Crit Care Med, Fac Med, Fukuoka, Japan

[13] Fukujuji Hosp, Kiyose, Japan

[14] Tohoku Univ, Dept Resp Med, Grad Sch Med, Sendai, Japan

[15] Osaka Saiseikai Nakatsu Hosp, Dept Resp Med, Osaka, Japan

[16] Showa Univ, Internal Med Ctr, Internal Med, Koto Toyosu Hosp, Tokyo, Japan

[17] Kanagawa Cardiovasc & Resp Ctr, Yokohama, Japan

[18] Sano Kosei Gen Hosp, Internal Med, Sano, Japan

[19] Tosei Gen Hosp, Dept Infect Dis, Seto, Japan

[20] Saiseikai Utsunomiya Hosp, Utsunomiya, Japan

[21] Ishikawa Prefectural Cent Hosp, Ishikawa, Kanazawa, Japan

[22] Keiyu Hosp, Yokohama, Japan

[23] Tokai Univ, Dept Med, Div Pulm Med, Sch Med, Isehara, Japan

[24] Fujisawa City Hosp, Dept Resp Med, Fujisawa, Japan

[25] Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Japan

[26] Univ Tokyo, Grad Sch Med, Dept Genome Informat, Tokyo, Japan

[27] RIKEN Ctr Integrat Med Sci, Lab Syst Genet, Yokohama, Kanagawa, Japan

[28] Tokyo Med & Dent Univ, Med Innovat Promot Ctr, Tokyo, Japan

[29] Keio Univ, Dept Surg, Sch Med, Tokyo, Japan

[30] Tokyo Med & Dent Univ, Inst Res, Tokyo, Japan

[31] Univ Tokyo, Inst Med Sci, Human Genome Ctr, Div Hlth Med Intelligence, Tokyo, Japan

[32] Tokyo Med & Dent Univ, M&D Data Sci Ctr, Tokyo, Japan

[33] Kyoto Univ, Dept Pathol & Tumor Biol, Kyoto, Japan

[34] Keio Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Sch Med, Tokyo, Japan

来源：

OPEN FORUM INFECTIOUS DISEASES | 2023年 / 10卷 / 07期

基金：

日本科学技术振兴机构;

关键词：

baricitinib; COVID-19; invasive mechanical ventilation; real-world data; HOSPITALIZED-PATIENTS; DEXAMETHASONE; PNEUMONIA;

D O I：

10.1093/ofid/ofad311

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background To determine the effectiveness of baricitinib in patients with coronavirus disease 2019 (COVID-19), investigate whether baricitinib prevents the need for invasive mechanical ventilation and identify patient subgroups that would benefit from baricitinib. Methods This observational matched-cohort study was conducted by the Japan COVID-19 Task Force, a nationwide multicenter consortium. Patients with COVID-19 aged & GE;18 years were identified from 70 hospitals in Japan. Among patients with confirmed COVID-19 from February 2020 to September 2021, those receiving baricitinib were propensity-score matched with controls. Results Among 3309 patients, 144 propensity score-matched pairs were identified. Thirteen (9.0%) patients in the baricitinib group and 27 (18.8%) in the control group required invasive mechanical ventilation during the disease course (odds ratio, 0.43). Although the baricitinib group had more severe disease, there were no significant differences in the intensive care unit admission rates (odds ratio, 1.16) and mortality rates (odds ratio, 0.74) between groups. In subgroup analyses, baricitinib was associated with a significant reduction in the need for invasive mechanical ventilation in patients requiring oxygen support (odds ratio, 0.28), with rapid shadow spread on chest radiography (odds ratio, 0.11), or treated with remdesivir (odds ratio, 0.27), systemic corticosteroids (odds ratio, 0.31), or anticoagulants (odds ratio, 0.17). Conclusions Baricitinib is effective at preventing the need for invasive mechanical ventilation in patients with COVID-19. Real-world data from patients in 70 hospitals in Japan showed that baricitinib is effective at preventing the need for invasive mechanical ventilation in patients with COVID-19.

引用

页数：10

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