Friend or foe: association of Euphorbia spp. with Epstein-Barr virus and Burkitt's lymphoma, an in silico approach

被引：0

作者：

Erdag, Emine ^{[1
]}

Ersalici, Ismet ^{[2
]}

Ozverel, Cenk Serhan ^{[3
,4
]}

机构：

[1] Near East Univ, Fac Pharm, Dept Pharmaceut Chem, CY-99138 Nicosia, Cyprus

[2] Near East Univ, Fac Dent, Dept Orthodont, CY-99138 Nicosia, Cyprus

[3] Near East Univ, Fac Dent, Basic Med Sci Dept, Med Microbiol, CY-99138 Nicosia, Cyprus

[4] Near East Univ, DESAM Res Inst, CY-99138 Nicosia, Cyprus

来源：

FUTURE VIROLOGY | 2023年 / 18卷 / 09期

关键词：

Burkitt's lymphoma; EBNA1; Epstein-Barr virus; Euphorbia spp; molecular docking; INHIBITORS;

D O I：

10.2217/fvl-2023-0011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: Epstein-Barr virus-related Burkitt's lymphoma (BL) is characterized by EBNA1 expression. Previous studies have hypothesized a correlation between Burkitt's lymphoma and endemicity of Euphorbia spp. whereas others have suggested it possesses antiviral activity. We aimed to investigate the effect of Euphorbia spp. on BL. Methods: AutoDock Vina, GROMACS 2020.4 and VEGA-QSAR were used for in silico assessments. Results: Daphnoretin had a higher binding affinity than the EBNA1 inhibitor VK0044, maintained a steady ligand RMSD value and displayed the largest negative binding energy at the EBNA1 active site. Conclusion: Daphnoretin, a phytochemical of Euphorbia spp., had superior inhibitory activity of EBNA1 over other tested chemicals, suggesting it is an effective therapeutic drug candidate.

引用

页码：583 / 594

页数：12