Intravitreal injection of Huperzine A promotes retinal ganglion cells survival and axonal regeneration after optic nerve crush

被引：3

作者：

Zhou, Lai-Yang ^{[1
,2
]}

Chen, Di ^{[3
]}

Guo, Xin-Ran ^{[1
]}

Niu, Yu-Qian ^{[4
]}

Xu, Yong-Sai ^{[5
]}

Feng, Dong-Fu ^{[2
]}

Li, Tie-Chen ^{[1
]}

机构：

[1] Wannan Med Coll, Sch Preclin Med, Wuhu, Peoples R China

[2] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Neurosurg, South Campus, Shanghai, Peoples R China

[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou, Peoples R China

[4] Jinzhou Med Univ, Fengxian Dist Cent Hosp Grad Student Training Base, Shanghai, Peoples R China

[5] Anhui Univ Sci & Technol, Sch Med, Huainan, Peoples R China

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2023年 / 17卷

关键词：

traumatic optic neuropathy (TON); Huperzine A (HupA); retinal ganglion cell (RGC); axonal regeneration; survival; mTOR; ADULT CNS; DRUG; NEUROPATHY; PROTECTION; MODULATION; PATHWAYS;

D O I：

10.3389/fncel.2023.1145574

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Traumatic optic neuropathy (TON) is a condition that causes massive loss of retinal ganglion cells (RGCs) and their axonal fibers, leading to visual insufficiency. Several intrinsic and external factors can limit the regenerative ability of RGC after TON, subsequently resulting in RGC death. Hence, it is important to investigate a potential drug that can protect RGC after TON and enhance its regenerative capacity. Herein, we investigated whether Huperzine A (HupA), extracted from a Chinese herb, has neuroprotective effects and may enhance neuronal regeneration following the optic nerve crush (ONC) model. We compared the three modes of drug delivery and found that intravitreal injection of HupA could promote RGC survival and axonal regeneration after ONC. Mechanistically, HupA exerted its neuroprotective and axonal regenerative effects through the mTOR pathway; these effects could be blocked by rapamycin. To sum up, our findings suggest a promising application of HupA in the clinical treatment of traumatic optic nerve.

引用

页数：10