Hydrogel-Based Strategies to Enhance T-Cell Performance for Solid Tumor Immunotherapy

被引：3

作者：

Oh, Seung Won ^{[1
]}

Kim, Pilnam ^{[1
,2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

[2] KAIST Inst Hlth Sci & Technol, Daejeon 34141, South Korea

来源：

ADVANCED THERAPEUTICS | 2024年 / 7卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

cancer immunotherapy; hydrogels; solid tumors; T cells; tumor microenvironment; EXTRACELLULAR-MATRIX; CANCER VACCINE; TGF-BETA; ANTITUMOR IMMUNITY; ALGINATE HYDROGELS; DENDRITIC CELLS; KILLER-CELLS; IN-VIVO; GM-CSF; ANTIGEN;

D O I：

10.1002/adtp.202300094

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The solid tumor microenvironment presents many challenges for immunotherapy that must be addressed for clinical relevance. This review will highlight research that has attempted to tackle these challenges and summarize recent therapeutic approaches to enhance both native and engineered T cell functions through hydrogel delivery. Different types of hydrogels are presented in this paper and organized based on purpose of the research: activation and expansion, delivery methods, co-delivery of immunostimulating agents, and overcoming tumor microenvironment barriers. Perspectives in the future of solid cancer immunotherapy are also discussed to share opinion on necessary research for the success in this field.

引用

页数：18

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