Longitudinal brain age prediction and cognitive function after stroke

被引：8

作者：

Aamodt, Eva B. ^{[1
,2
]}

Alnaes, Dag ^{[1
,3
]}

de Lange, Ann-Marie G. ^{[1
,3
,4
,5
,6
]}

Aam, Stina ^{[7
,8
]}

Schellhorn, Till ^{[1
,2
]}

Saltvedt, Ingvild ^{[7
,8
]}

Beyer, Mona K. ^{[1
,2
]}

Westlye, Lars T. ^{[1
,3
,9
,10
]}

机构：

[1] Univ Oslo, Inst Clin Med, Oslo, Norway

[2] Oslo Univ Hosp, Div Radiol & Nucl Med, Oslo, Norway

[3] Univ Oslo, Oslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway

[4] Lausanne Univ Hosp CHUV, Ctr Res Neurosci, Dept Clin Neurosci, LREN, Lausanne, Switzerland

[5] Univ Lausanne, Lausanne, Switzerland

[6] Univ Oxford, Dept Psychiat, Oxford, England

[7] NTNU Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway

[8] Trondheim Reg & Univ Hosp, Dept Geriatr, Clin Med, St Olavs Hosp, Trondheim, Norway

[9] Univ Oslo, Dept Psychol, Oslo, Norway

[10] Univ Oslo, KG Jebsen Ctr Neurodev Disorders, Oslo, Norway

来源：

NEUROBIOLOGY OF AGING | 2023年 / 122卷

关键词：

Post -stroke dementia; Aging; Imaging; Biomarker; Longitudinal; Cognitive decline; IMPAIRMENT; RISK; MEMORY; COHORT; SEGMENTATION; MULTICENTER; DEMENTIA; PROTOCOL; VOLUMES; SCALE;

D O I：

10.1016/j.neurobiolaging.2022.10.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Advanced age is associated with post-stroke cognitive decline. Machine learning based on brain scans can be used to estimate brain age of patients, and the corresponding difference from chronological age, the brain age gap (BAG), has been investigated in a range of clinical conditions, yet not thoroughly in post-stroke neurocognitive disorder (NCD). We aimed to investigate the association between BAG and post-stroke NCD over time. Lower BAG (younger appearing brain compared to chronological age) was found associated with lower risk of post-stroke NCD up to 36 months after stroke, even among those showing no evidence of impairments 3 months after hospital admission. For patients with no NCD at baseline, survival analysis suggested that higher baseline BAG was associated with higher risk of post -stroke NCD at 18 and 36 months. In conclusion, a younger appearing brain is associated with a lower risk of post-stroke NCD.(c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

引用

页码：55 / 64

页数：10