Association between Levels of Trimethylamine N-Oxide and Cancer: A Systematic Review and Meta-Analysis

被引:6
作者
Khodabakhshi, Adeleh [1 ,2 ,3 ]
Monfared, Vahid [4 ]
Arabpour, Zahra [5 ]
Vahid, Farhad [6 ]
Hasani, Motahareh [7 ]
机构
[1] Kerman Univ Med Sci, Student Res Comm, Kerman, Iran
[2] Kerman Univ Med Sci, Fac Publ Hlth, Physiol Res Ctr, Inst Neuropharmacol, Kerman, Iran
[3] Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran
[4] Semnan Univ Med Sci, Student Res Comm, Semnan, Iran
[5] Kerman Univ Med Sci, Sch Hlth, Dept Nutr, Kerman, Iran
[6] Luxembourg Inst Hlth, Dept Precis Hlth, Nutr & Hlth Res Grp, Strassen, Luxembourg
[7] Golestan Univ Med Sci, Sch Hlth, Dept Nutr, Gorgan, Golestan, Iran
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2023年 / 75卷 / 02期
关键词
OXIDATIVE STRESS; RISK; INFLAMMATION; CHOLINE; BIOMARKERS; TMAO; CARCINOMA; CARNITINE; COHORT;
D O I
10.1080/01635581.2022.2129080
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer is the second leading cause of death in the world. Reports on the effect of Trimethylamine-N-oxide (TAMO), a small amine oxide generated by gut microbial metabolism of choline, betaine, and carnitine, on cancer are inconsistent. Therefore, this systematic review and meta-analysis summarize the effect of TAMO on cancer incidence. A systematic search was conducted in PubMed, Scopus, Web of Science, and Embase. Data were pooled using the random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). The pooled results of 16 studies, including 5930 participants, showed that the association between TMAO levels and cancer incidence is insignificant (Odds Ratio: 0.97, 95% CI: (0.64, 1.46), P-value = 0.871). Subgroup analysis showed that urinary TMAO levels were negatively associated with cancer incidence; in contrast, a direct and positive association was observed between serum TMAO levels and cancer incidence. However, "gender" and the "TMAO measuring method" were the potential sources of discrepancies. Meta-regression analysis did not reveal any significant association between duration of studies, age, female ratio, subjects-control, and subjects-case. The present study demonstrates that serum TAMO levels were insignificantly associated with cancer incidence.
引用
收藏
页码:402 / 414
页数:13
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