Fusidic Acid Microemulsion Based on a Pseudoternary Phase Diagram: Development, Characterization, and Evaluation

Purpose Microemulsions (MEs) are homogeneous, optically clear and thermodynamically stable systems intended to increase the bioavaibility, solubility, and entrapment of drugs. In this study, a new system of oil-in-water MEs was formulated with Fusidic acid as a drug. MEs were composed of Isopropyl myristate, non-ionic surfactants tween 80, 1-propanol and water. Methods The optimum weight ratios of components and MEs areas were determined by pseudoternary phase diagram. The prepared microemulsions were evaluated regarding their stability, pH, refractive index, conductivity, viscosity, particle size, zeta potential, surface tension and partition coefficient. Results These parameters suggested that the optimized MEs were stable and optically clear. Conclusion This study reveals that the product can be used for ocular treatment.