The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis

被引：14
作者：
Xie, Guoping [1 ]
Chen, Huan [2 ]
He, Chan [3 ]
Hu, Siheng [4 ]
Xiao, Xue [5 ]
Luo, Qunying [6 ]
机构：
[1] Wuhan Iron & Steel Grp Corp, Dept Clin Lab, Staff Hosp 2, Wuhan, Hubei, Peoples R China
[2] Wuhan Inst Technol, Wuhan Inst Technol Hosp, Dept Clin Lab, Wuhan, Peoples R China
[3] Maternal & Child Hlth Hosp Wuchang Dist, Dept Clin Lab, Wuhan, Hubei, Peoples R China
[4] Honggangcheng St Community Hlth Serv Ctr, Dept Clin Lab, Wuhan, Hubei, Peoples R China
[5] Gongrencun St Community Hlth Serv Ctr, Dept Clin Lab, Wuhan, Peoples R China
[6] Huarun Wuhan Iron & Steel Gen Hosp, Dept Neurol, Wuhan, Hubei, Peoples R China
来源：
FUNCTIONAL & INTEGRATIVE GENOMICS | 2023年 / 23卷 / 03期
关键词：
Epilepsy; miRNA; Inflammation; Apoptosis; IMMATURE RAT MODEL; NF-KAPPA-B; MESSENGER-RNA; MICRORNA EXPRESSION; STATUS EPILEPTICUS; DOWN-REGULATION; NEURONAL EXCITABILITY; NUCLEAR EXPORT; CELL APOPTOSIS; SEIZURES;
D O I：
10.1007/s10142-023-01220-y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Epilepsy is a neurological disorder that impacts millions of people worldwide, and it is characterized by the occurrence of recurrent seizures. The pathogenesis of epilepsy is complex, involving dysregulation of various genes and signaling pathways. MicroRNAs (miRNAs) are a group of small non -coding RNAs that play a vital role in the regulation of gene expression. They have been found to be involved in the pathogenesis of epilepsy, acting as key regulators of neuronal excitability and synaptic plasticity. In recent years, there has been a growing interest in exploring the miRNA regulatory network in epilepsy. This review summarizes the current knowledge of the regulatory miRNAs involved in inflammation and apoptosis in epilepsy and discusses its potential as a new avenue for developing targeted therapies for the treatment of epilepsy.
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页数：17
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共 148 条
  • [11] Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy
    Brennan, Gary P.
    Bauer, Sebastian
    Engel, Tobias
    Jimenez-Mateos, Eva M.
    Del Gallo, Federico
    Hill, Thomas D. M.
    Connolly, Niamh M. C.
    Costard, Lara S.
    Neubert, Valentin
    Salvetti, Beatrice
    Sanz-Rodriguez, Amaya
    Heiland, Mona
    Mamad, Omar
    Brindley, Elizabeth
    Norwood, Braxton
    Batool, Aasia
    Raoof, Rana
    El-Naggar, Hany
    Reschke, Cristina R.
    Delanty, Norman
    Prehn, Jochen H. M.
    Fabene, Paolo
    Mooney, Catherine
    Rosenow, Felix
    Henshall, David C.
    [J]. NEUROBIOLOGY OF DISEASE, 2020, 144
  • [12] MicroRNA-21 protects neurons from ischemic death
    Buller, Ben
    Liu, Xianshuang
    Wang, Xinli
    Zhang, Rui L.
    Zhang, Li
    Hozeska-Solgot, Ann
    Chopp, Michael
    Zhang, Zheng G.
    [J]. FEBS JOURNAL, 2010, 277 (20) : 4299 - 4307
  • [13] Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
    Cai, XZ
    Hagedorn, CH
    Cullen, BR
    [J]. RNA, 2004, 10 (12) : 1957 - 1966
  • [14] AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome
    Campbell, Aoife
    Morris, Gareth
    Sanfeliu, Albert
    Augusto, Joana
    Langa, Elena
    Kesavan, Jaideep C.
    Nguyen, Ngoc T.
    Conroy, Ronan M.
    Worm, Jesper
    Kielpinski, Lukasz
    Jensen, Mads Aaboe
    Miller, Meghan T.
    Kremer, Thomas
    Reschke, Cristina R.
    Henshall, David C.
    [J]. MOLECULAR THERAPY NUCLEIC ACIDS, 2022, 28 : 514 - 529
  • [15] Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice
    Campbell, Aoife
    Morris, Gareth
    Heller, Janosch P.
    Langa, Elena
    Brindley, Elizabeth
    Worm, Jesper
    Jensen, Mads Aaboe
    Miller, Meghan T.
    Henshall, David C.
    Reschke, Cristina R.
    [J]. SCIENTIFIC REPORTS, 2021, 11 (01)
  • [16] Involvement of microRNAs in epileptogenesis
    Cattani, Adriano A.
    Allene, Camille
    Seifert, Volker
    Rosenow, Felix
    Henshall, David C.
    Freiman, Thomas M.
    [J]. EPILEPSIA, 2016, 57 (07) : 1015 - 1026
  • [17] Mechanisms of disease - Epilepsy
    Chang, BS
    Lowenstein, DH
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (13) : 1257 - 1266
  • [18] Aberrant Expression of miR-323a-5p in Patients with Refractory Epilepsy Caused by Focal Cortical Dysplasia
    Che, Ningwei
    Zu, Guo
    Zhou, Tingting
    Wang, Xiaofeng
    Sun, Yuqiang
    Tan, Zeshi
    Liu, Yaoling
    Wang, Dong
    Luo, Xiaodong
    Zhao, Ze
    Zhang, Yue
    Wei, Minghai
    Yin, Jian
    [J]. GENETIC TESTING AND MOLECULAR BIOMARKERS, 2017, 21 (01) : 3 - 9
  • [19] miR-128 is upregulated in epilepsy and promotes apoptosis through the SIRT1 cascade
    Chen, De-Zhe
    Wang, Wei-Wei
    Chen, Yan-Ling
    Yang, Xia-Feng
    Zhao, Min
    Yang, Yan-Yan
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2019, 44 (02) : 694 - 704
  • [20] TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    Chendrimada, TP
    Gregory, RI
    Kumaraswamy, E
    Norman, J
    Cooch, N
    Nishikura, K
    Shiekhattar, R
    [J]. NATURE, 2005, 436 (7051) : 740 - 744
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