Allostatic Load, Morbidity, and Mortality Among Older Adults: A Multi-Wave Analysis From the National Health and Aging Trends Study

被引：4

作者：

Polick, Carri S. ^{[1
,2
,8
]}

Harris-Gersten, Melissa L. ^{[1
,2
]}

Dennis, Paul A. ^{[1
,3
]}

Noonan, Devon ^{[2
]}

Hastings, Susan N. ^{[1
,4
]}

Calhoun, Patrick S. ^{[5
,6
]}

Rosemberg, Marie Anne ^{[7
]}

Stoddard, Sarah A. ^{[7
]}

机构：

[1] Durham VA Hlth Care Syst, Ctr Accelerate Discovery & Practice Transformat, Durham, NC USA

[2] Duke Univ Sch Nursing, Durham, NC USA

[3] Duke Univ Sch Med, Dept Populat Hlth Sci, Durham, NC USA

[4] Duke Univ Sch Med, Dept Med, Durham, NC USA

[5] VA Midatlant Mental Illness Res Educ & Clin Ctr MI, Durham, NC USA

[6] Duke Univ Sch Med, Dept Psychiat & Behav Sci, Durham, NC USA

[7] Univ Michigan Sch Nursing, Ann Arbor, MI USA

[8] Duke Univ Sch Nursing, 307 Trent Dr, Durham, NC 27710 USA

来源：

JOURNAL OF APPLIED GERONTOLOGY | 2024年 / 43卷 / 08期

关键词：

chronic conditions; morbidity; mortality; Allostatic Load; Older Adults; CUMULATIVE BIOLOGICAL RISK; MACARTHUR; DISEASE;

D O I：

10.1177/07334648241230010

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

Although allostatic load (AL) is a key concept to reflect physiologic wear and tear from stress, older adults are underrepresented in AL-related research, especially the oldest old (>= 80). Further, attenuative factors are often unaccounted for. This longitudinal analysis using data from National Health and Aging Trends Study investigated relationships of AL in 2017 and multi-wave (1) comorbidity accumulation using multilevel Poisson modeling and (2) mortality risk using survival analysis. By year five (2022), each incremental AL increase that older adults (n = 3614) experienced was associated with a 47% increase in comorbidity (p < .001), and a 33% increased mortality risk (p < .001). This research supports a shift to a more proactive, health promotion/risk mitigation paradigm through informing intervention research targeting AL, which is currently scarce. Identifying potentially modifiable and key driving factors influencing the relationship between AL and health among older adults is an important next step to inform intervention design.

引用

页码：1052 / 1059

页数：8

共 30 条

[1]

[Anonymous], 2022, Global roadmap for healthy longevity, DOI [DOI 10.17226/26144, 10.17226/26144]

[2] Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: Pilot results from a randomized controlled comparative efficacy [J].

Carroll, Judith E. ;

Seeman, Teresa E. ;

Olmstead, Richard ;

Melendez, Gerson ;

Sadakane, Ryan ;

Bootzin, Richard ;

Nicassio, Perry ;

Irwin, Michael R. .

PSYCHONEUROENDOCRINOLOGY, 2015, 55 :184-192

[3] Age differences in allostatic load: an index of physiological dysregulation [J].

Crimmins, EM ;

Johnston, M ;

Hayward, M ;

Seeman, T .

EXPERIMENTAL GERONTOLOGY, 2003, 38 (07) :731-734

[4] Cigarette Smoking, Smoking Cessation, and Long-Term Risk of 3 Major Atherosclerotic Diseases [J].

Ding, Ning ;

Sang, Yingying ;

Chen, Jingsha ;

Ballew, Shoshana H. ;

Kalbaugh, Corey A. ;

Salameh, Maya J. ;

Blaha, Michael J. ;

Allison, Matthew ;

Heiss, Gerardo ;

Selvin, Elizabeth ;

Coresh, Josef ;

Matsushita, Kunihiro .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 74 (04) :495-504

[5] Statistical procedures for analyzing mental health services data [J].

Elhai, Jon D. ;

Calhoun, Patrick S. ;

Ford, Julian D. .

PSYCHIATRY RESEARCH, 2008, 160 (02) :129-136

[6] Allostatic load and stress biomarkers in a sample of community-dwelling older adults [J].

Falcao Freire, Aline do Nascimento ;

de Souza Barbosa, Juliana Fernandes ;

Pereira, Daniele Sirineu ;

Gomes, Cristiano dos Santos ;

Guerra, Ricardo Oliveira .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2020, 87

[7] Cohort Profile: The National Health and Aging Trends Study (NHATS) [J].

Freedman, Vicki A. ;

Kasper, Judith D. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2019, 48 (04) :1044-+

[8] Chronic inflammation in the etiology of disease across the life span [J].

Furman, David ;

Campisi, Judith ;

Verdin, Eric ;

Carrera-Bastos, Pedro ;

Targ, Sasha ;

Franceschi, Claudio ;

Ferrucci, Luigi ;

Gilroy, Derek W. ;

Fasano, Alessio ;

Miller, Gary W. ;

Miller, Andrew H. ;

Mantovani, Alberto ;

Weyand, Cornelia M. ;

Barzilai, Nir ;

Goronzy, Jorg J. ;

Rando, Thomas A. ;

Effros, Rita B. ;

Lucia, Alejandro ;

Kleinstreuer, Nicole ;

Slavich, George M. .

NATURE MEDICINE, 2019, 25 (12) :1822-1832

[9] Allostatic Load and Frailty in Older Adults [J].

Gruenewald, Tara L. ;

Seeman, Teresa E. ;

Karlamangla, Arun S. ;

Sarkisian, Catherine A. .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2009, 57 (09) :1525-1531

[10] Association of Childhood Adversity With Morbidity and Mortality in US Adults A Systematic Review [J].

Grummitt, Lucinda Rachel ;

Kreski, Noah T. ;

Kim, Stephanie Gyuri ;

Platt, Jonathan ;

Keyes, Katherine M. ;

McLaughlin, Katie A. .

JAMA PEDIATRICS, 2021, 175 (12) :1269-1278

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