Longitudinal association between saliva and hair cortisol concentration: A systematic comparison

被引:4
作者
Solorzano, Claudio Singh [1 ,2 ]
Serwinski, Bianca [1 ,3 ]
Grano, Caterina [2 ]
Steptoe, Andrew [1 ]
机构
[1] UCL, Dept Behav Sci & Hlth, 1-19 Torrington Pl, London WC1E 6BT, England
[2] Sapienza Univ, Dept Psychol, Via Marsi 78, I-00185 Rome, Italy
[3] Northeastern Univ London, Devon House, 58 St Katharines Way, London E1W 1LP, England
基金
英国医学研究理事会;
关键词
Hair cortisol; Salivary cortisol; Cortisol concentration; Comparison; AWAKENING RESPONSE; CHRONIC STRESS; BIOMARKER; SERUM; TIME;
D O I
10.1016/j.psyneuen.2023.106340
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cortisol assays from hair have become increasingly common in psychoneuroendocrinological research as in-dicators of long-term output relevant to stress and health outcomes. Comparisons of hair cortisol concentration (HCC) with salivary samples have produced mixed findings, and it remains unclear which aspects of the diurnal salivary profile correspond most closely to HCC, and what time intervals between saliva and hair sampling are most relevant, taking the rate of hair growth into account. This longitudinal study aimed to evaluate the cor-respondence between HCC and parameters of total salivary cortisol output in the morning (CARauc and CARi) and during the rest of the day excluding the early morning period (DAYauc), by systematically studying three time periods - two weeks, four weeks, and six weeks - before hair sampling. At each time period, 54 female university students (mean age: 20.85 & PLUSMN; 1.16 years) provided three saliva cortisol samples on day 1 at 11 am, 3 pm, at bedtime, then two samples the following day on waking and 30 min after awakening. Hair strand collection (1 cm nearest the scalp) took place two weeks after the last saliva sample. Results of multivariable regressions indicate that HCC was consistently associated with DAYauc for all three time periods and with the aggregate DAYauc across days after adjusting for age, body mass index, smoking, oral contraceptive use, hair washing frequency and hair treatments. The strongest associations were found for DAYauc two weeks before hair sampling (& beta; = 0.578, p < 0.001) and the aggregated DAYauc across all three time periods (& beta; = 0.596, p < 0.001), although the confidence intervals overlapped those for four and six week analyses. There was no significant association between HCC and either CARauc or CARi. Our study confirms that hair cortisol could be a reliable retrospective biomarker of basal and long-term cortisol output secretion at least up to six weeks earlier. The results contribute to a better understanding of the different associations between HCC and salivary cortisol in the morning and the rest of the day, while also having implications for the use of HCC as an outcome measure in intervention and treatment research.
引用
收藏
页数:6
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