The Role of Gut Microbiota in Blood-Brain Barrier Disruption after Stroke

被引：7

作者：

Zeng, Meiqin ^{[1
,2
]}

Peng, Meichang ^{[1
,2
]}

Liang, Jianhao ^{[1
,2
]}

Sun, Haitao ^{[1
,2
,3
]}

机构：

[1] Southern Med Univ, Zhujiang Hosp, Guangdong Prov Clin Res Ctr Lab Med, Clin Biobank Ctr,Microbiome Med Ctr,Dept Lab Med, Guangzhou 510280, Peoples R China

[2] Southern Med Univ, Guangdong Prov Key Lab Brain Funct Repair & Regene, Educ Minist China Diag & Treatment Cerebrovasc Dis, Neurosurg Inst Guangdong Prov,Zhujiang Hosp,Neuros, Guangzhou 510282, Peoples R China

[3] Southern Med Univ, Guangdong Hong Kong Macao Greater Bay Area Ctr Bra, Minist Educ, Key Lab Mental Hlth, Guangzhou, Guangdong, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2024年 / 61卷 / 12期

关键词：

Stroke; Gut microbiota; Blood-brain barrier; Microbiota-gut-brain axis; TIGHT JUNCTION DISRUPTION; COGNITIVE IMPAIRMENT; ISCHEMIC-STROKE; MEDIATED DISRUPTION; CEREBRAL-ISCHEMIA; ENDOTHELIAL-CELLS; BONE-MARROW; PROTECTS; EXPRESSION; PERICYTES;

D O I：

10.1007/s12035-023-03512-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Growing evidence has proved that alterations in the gut microbiota have been linked to neurological disorders including stroke. Structural and functional disruption of the blood-brain barrier (BBB) is observed after stroke. In this context, there is pioneering evidence supporting that gut microbiota may be involved in the pathogenesis of stroke by regulating the BBB function. However, only a few experimental studies have been performed on stroke models to observe the BBB by altering the structure of gut microbiota, which warrant further exploration. Therefore, in order to provide a novel mechanism for stroke and highlight new insights into BBB modification as a stroke intervention, this review summarizes existing evidence of the relationship between gut microbiota and BBB integrity and discusses the mechanisms of gut microbiota on BBB dysfunction and its role in stroke.

引用

页码：9735 / 9755

页数：21

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